PMID: 6159481Nov 1, 1980Paper

Characterization of a unique defective type C virus associated with a Moloney leukemia virus-induced splenic T-cell lymphoma cell line

Journal of Virology
I HorakJ N Ihle

Abstract

Moloney leukemia virus (MoLV) induces lymphomas in BALB/c mice which either involve an immature thymic T-cell subpopulation or a splenic mature T-cell subpopulation. To investigate further the possible virological and immunological differences in these lymphomas, several lymphoma cell lines were derived. Although the majority of these cell lines expressed only the parental MoLV, one lymphoma cell line (5F4) was found which expressed only a defective virus. 5F4 virions lacked detectable reverse transcriptase activity and by immunoprecipitation lacked a serologically detectable reverse transcriptase. The lack of reverse transcriptase did not appear to be due to a deletion in the viral genome. Intracellularly 5F4 cells synthesized normal gag gene precursors but had little, if any, detectable Pr180gag-pol or an altered precursor. These results suggest that the defect of the 5F4 virus is associated with the inability to translate the appropriate precursor for reverse transcriptase. The possible origin of the detective 5F4 virus was also examined by competition radioimmunoassays. These results demonstrate that the type-specific proteins, gp71 and p12, are serologically identical to those of the endogenous ecotropic virus and distinct...Continue Reading

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G K McMaster, G G Carmichael
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A DeclèveH S Kaplan
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J W HartleyW P Rowe
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J H ElderW P Rowe
Apr 1, 1978·The Journal of Experimental Medicine·N Rosenberg, D Baltimore
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E Canaani, S A Aaronson
Nov 1, 1978·Cell·D Steffen, R A Weinberg
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Feb 19, 1971·Nature·R H BassinP J Fischinger
Mar 1, 1980·The Journal of Experimental Medicine·M W CloydW P Rowe
Apr 1, 1980·Journal of Virology·P NeimanR A Weiss

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