Characterization of acetylcholine receptor antibodies in a patient with primary biliary cirrhosis

Acta Neurologica Scandinavica
A K Lefvert, G Holm

Abstract

Antibodies against the acetylcholine receptor were found in a patient with primary biliary cirrhosis. The patient had no clinical or electrophysiological evidence of disturbed neuromuscular function. The antibodies were of both IgG and IgM isotype. Following passive transfer, these antibodies showed the same capacity to bind in vivo to mouse muscle receptors as immunoglobulins from patients with myasthenia gravis. The affinity of the antibodies was high and comparable to that found in myasthenia gravis patients.

References

Jan 1, 1978·Scandinavian Journal of Immunology·A K Lefvert, K Bergström
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E YaoitaI Kihara
Nov 1, 1987·Clinical Immunology and Immunopathology·A C SundewallR Norberg
Jan 1, 1985·Acta Medica Scandinavica·A C SundewallR Olsson

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Citations

Apr 7, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Raed BehbehaniJ T Anim
Jun 1, 1992·The Japanese Journal of Psychiatry and Neurology·Z P QuZ Hong
Sep 1, 1991·Postgraduate Medical Journal·P ButlerA K Burroughs
Jul 24, 2004·Journal of the American Geriatrics Society·Peter McCann, A Pramanik
Dec 17, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Rolando CimazRenzo Guerrini

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