PMID: 15252284Jul 15, 2004Paper

Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice

Alcoholism, Clinical and Experimental Research
Igor Ponomarev, John C Crabbe

Abstract

Acute functional tolerance (AFT) to ethanol-induced hypnosis is one of the main factors that affect the duration of ethanol-induced loss of righting reflex (LRR: "sleep time"). Investigators who use duration of LRR as a measure of ethanol-induced sedation should consider the potential magnitude and time course of this neuroadaptation when interpreting their results. However, AFT to the hypnotic effects of ethanol has not been well characterized. The present study explored this form of AFT using a novel method of monitoring LRR in mice. Genetically heterogeneous mice were used to study effects of dose and time on the development of AFT. Mice were treated with different dose regimens and tested for LRR after hypnotic doses using a cylindrical restrainer. Measures of initial sensitivity and AFT to ethanol-induced hypnosis were calculated and analyzed. Inbred strains of mice were then characterized for AFT magnitude after a single ethanol dose. Results showed that (a) AFT developed in a dose-dependent fashion but attained an apparent maximum value; (b) AFT to ethanol-induced hypnosis could develop partially after a small, subhypnotic dose; (c) AFT developed very rapidly and approached its maximum for a given dose by the 10th min af...Continue Reading

References

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Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Igor Ponomarev, John C Crabbe

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Citations

Mar 1, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elissa J CheslerAndrew Holmes
Sep 29, 2005·Behavioral Neuroscience·Pamela Metten, John C Crabbe
Sep 12, 2006·Addiction Biology·John C CrabbeGeorge F Koob
Apr 10, 2008·Genes, Brain, and Behavior·M K MulliganS E Bergeson
Dec 7, 2013·PloS One·Sean P Farris, Michael F Miles
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Amanda L SharpeTamara J Phillips
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Chi-ming Huang, Rosa H Huang
Jun 21, 2008·Alcoholism, Clinical and Experimental Research·Benjamin PalachickAndrew Holmes
Feb 9, 2012·Alcoholism, Clinical and Experimental Research·John C CrabbePamela Metten
Jul 31, 2013·Alcoholism, Clinical and Experimental Research·Richard A RadcliffeBeth Bennett
Apr 4, 2015·Alcoholism, Clinical and Experimental Research·Beth BennettRichard A Radcliffe
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·John C CrabbeDouglas Wahlsten
Aug 11, 2006·Pharmacology, Biochemistry, and Behavior·Richard A RadcliffeMichael J Lee
Mar 31, 2010·The Biochemical Journal·Philip M Newton, Robert O Messing
Apr 23, 2008·Current Protocols in Neuroscience·John C CrabbeDouglas Wahlsten

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