Characterization of acute HIV-1 infection in high-risk Nigerian populations.

The Journal of Infectious Diseases
Man CharuratWilliam Blattner

Abstract

Acute phase of human immunodeficiency virus (HIV) infection (AHI) may account for a significant proportion of HIV-1 transmission. We identified and characterized individuals in Nigeria with AHI. Individuals were tested using a combination of rapid HIV testing in mobile units and laboratory-based specimen pooling for nucleic acid amplification testing. Genome sequences were characterized. A linear segmented regression model was fit to serial viral load (VL) measurements to characterize early VL profiles. Sixteen AHIs were identified from 28 655 persons screened. Specimens were genotyped: 7 (43.8%) were CRF02_AG, 6 (37.5%) were subtype G, 1 (6.3%) was CRF06_cpx, and 2 (12.5%) were unique recombinant forms. No antiretroviral resistance mutations were detected. The mean duration of high VL burden from peak to nadir was 76 days (95% confidence interval [CI], 58-93 days), and the mean rate of viremic control was -0.66 log(10) VL per month. The mean VL at set-point was 4.5 log(10) copies/mL (95% CI, 3.9-5.1 log(10) copies/mL). This study is the first to characterize AHI among Nigerians identified as HIV infected before seroconversion who would be otherwise missed by conventional HIV testing. Infections by HIV subtypes in Nigeria exhib...Continue Reading

References

Dec 1, 1994·Computer Applications in the Biosciences : CABIOS·S W SmithP M Gillevet
Nov 1, 1995·AIDS Research and Human Retroviruses·M O SalminenF E McCutchan
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·S J GangeJ B Margolick
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·F R CleghornM L Greenberg
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Christopher D PilcherSusan A Fiscus
Nov 1, 2002·Journal of Hypertension·Katarzyna StolarzEoin T O'Brien
May 4, 2004·The Journal of Infectious Diseases·William A BlattnerMichael Greenberg
Apr 6, 2005·The Journal of Infectious Diseases·Myron S Cohen, Christopher D Pilcher
Apr 6, 2005·The Journal of Infectious Diseases·Maria J WawerThomas C Quinn
May 6, 2005·The New England Journal of Medicine·Christopher D PilcherPeter A Leone
Jan 28, 2006·AIDS Research and Human Retroviruses·Simon M AgwaleRainer Ziermann
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sigall KassuttoEric S Rosenberg
Apr 18, 2008·Briefings in Bioinformatics·Sudhir KumarKoichiro Tamura

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Citations

May 30, 2013·PloS One·Kelly A CurtisS Michele Owen
Oct 15, 2014·AIDS Research and Human Retroviruses·Kelly A CurtisS Michele Owen
Sep 9, 2015·The Journal of Infectious Diseases·Mohammad M SajadiGeorge K Lewis
Dec 10, 2016·PloS One·Ogbonnaya S NjokuNelson L Michael
Aug 2, 2017·HIV Medicine·A A AdetunjiB O Taiwo
Nov 29, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jibreel JumareWalter Royal
May 21, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erik BillingsUNKNOWN MHRP Viral Sequencing Core and the TRUST/RV368 Study Group
Nov 10, 2017·Archives of Virology·Babatunde A OlusolaGeorgina N Odaibo
Feb 17, 2021·Journal of Medical Virology·Babatunde A OlusolaGeorgina N Odaibo

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