PMID: 7541641May 1, 1995Paper

Characterization of add(1)(p36) in non-Hodgkin lymphomas by fluorescence in situ hybridization

Genes, Chromosomes & Cancer
S BajalicaM Nordenskjöld

Abstract

Chromosome rearrangements involving chromosome I, band p36, are among the most common aberrations in non-Hodgkin lymphomas (NHL). We have studied nine cases of NHL with add(1)(p36) using fluorescence in situ hybridization (FISH) from a series of 205 cases. Five were follicular low-grade NHL and four were follicular or diffuse high-grade NHL. Three of the five cases with follicular low-grade NHL did not contain the 14;18 translocation. The extra material on the add(1)(p36) in these three cases was derived from chromosome segment 2q31-qter; in one it was observed as a sole clonal rearrangement. In the two remaining cases, with t(14;18), the add(1)(p36) consisted of material from chromosome arms 3q and 17q, respectively. In the four cases of high-grade NHL, the material added on to Ip36 was derived from chromosomes 6, 9, 17, and 19, respectively. Using a Ip36-specific probe, DIS94, we showed a deletion on the add(1) in one of the cases with low-grade NHL, whereas no loss was observed in one of the cases with high-grade NHL. Our study indicates that cytogenetically similar add(1)(p36) are found in both high- and low-grade NHL, and the breakpoint on Ip36 as well as the origin of translocated material may vary.

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Citations

Aug 1, 1996·Genes, Chromosomes & Cancer·M SchwabL C Amler
Jun 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A SzelesE R Zabarovsky
Sep 1, 1996·Cancer Genetics and Cytogenetics·S Bajalica-LagercrantzM Nordenskjöld
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Mar 25, 1999·European Journal of Haematology·M JerkemanF Mitelman
Oct 13, 2001·The Journal of Biological Chemistry·J E PrescottC V Dang

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