PMID: 15220221Jun 29, 2004Paper

Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies

Diabetes
Corinna SchoelchAndreas W Herling

Abstract

Increased supply of fatty acids to muscle and liver is causally involved in the insulin resistance syndrome. Using a tissue microdialysis technique in Wistar and Zucker fatty (ZF) rats, we determined tissue glycerol levels as a marker of lipolysis in gastrocnemius muscle (gMT), subcutaneous adipose (SAT), and visceral adipose tissue (VAT) as well as the reduction of plasma free fatty acids, glycerol, and triglycerides caused by the antilipolysis-specific adenosine-A1 receptor agonist (ARA). In Wistar and ZF rats, ARA significantly lowered dialysate glycerol levels in SAT, VAT, and gMT. Whereas in SAT and VAT the decrease in dialysate glycerol indicated adipocytic antilipolysis, this decrease in gMT was not caused by a direct effect of ARA on intramyocellular lipolysis, as demonstrated by the lack of inhibition of the protein kinase A activity ratio in gMT. In addition, no differences of the fed-starved-refed dynamics of intramyocellular triglyceride levels compared with untreated controls were measured by in vivo (1)H-spectroscopy, excluding any adenylate cyclase-independent antilipolysis in muscle. Treatment with ARA resulted in pronounced reductions of plasma free fatty acids, glycerol, and triglycerides. Furthermore, in ZF r...Continue Reading

References

Mar 1, 1979·Biochemical Pharmacology·P B Wieser, T S Pendleton
Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·J HellmérP Arner
May 1, 1992·The Journal of Clinical Investigation·P A JanssonP Lönnroth
Feb 7, 1992·Journal of Medicinal Chemistry·K A JacobsonM Williams
Dec 1, 1991·Metabolism: Clinical and Experimental·K N FraynS M Humphreys
May 1, 1991·The American Journal of Physiology·M J LaduW K Palmer
Nov 1, 1990·The Journal of Clinical Investigation·P ArnerM Brönnegård
Jul 1, 1990·Physiological Reviews·R A Olsson, J D Pearson
Jan 1, 1990·Progress in Neurobiology·H Benveniste, P C Hüttemeier
Dec 1, 1989·The American Journal of Physiology·S J VannucciK F LaNoue
Jun 1, 1986·The American Journal of Physiology·S E Martin, E L Bockman
Sep 1, 1982·Metabolism: Clinical and Experimental·S K FriedF X Pi-Sunyer
Mar 23, 1995·Molecular and Cellular Biochemistry·L HeseltineR Taylor
Jan 7, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V Mohamed-AliS W Coppack
Feb 10, 1999·The American Journal of Physiology·S W CoppackJ M Miles
Jan 10, 2002·Cellular Signalling·Markus KlingerChristian Nanoff
Nov 28, 2002·Diabetes·Eva Hagström-ToftPeter Arner

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Citations

Jul 7, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B GharibiB A J Evans
Dec 7, 2011·Circulation·Milka KoupenovaKatya Ravid
Aug 1, 2012·PloS One·Hillary Johnston-CoxKatya Ravid
Jan 29, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Maria Silvia Mariani Pires-de-CamposDora Maria Grassi-Kassisse
Dec 30, 2008·The Journal of Surgical Research·Kohei SatohYuzo Yamamoto
Sep 16, 2008·European Journal of Pharmacology·Stina M JohanssonBertil B Fredholm
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Oct 12, 2013·Journal of Cellular Physiology·Anna Eisenstein, Katya Ravid
Jul 25, 2006·Comptes rendus biologies·Dominique Langin
Apr 29, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dominique Langin
Jul 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefania MerighiStefania Gessi
Feb 18, 2015·Nature Reviews. Endocrinology·Luca AntonioliGyörgy Haskó
Mar 28, 2012·European Journal of Pharmacology·Ming YangArvinder K Dhalla
Feb 6, 2017·Molecular Aspects of Medicine·Andrea LeivaLuis Sobrevia
Dec 19, 2017·Frontiers in Pharmacology·Marco Tozzi, Ivana Novak
Mar 6, 2013·Journal of Cellular Physiology·Milka Koupenova, Katya Ravid
Jan 6, 2007·The Journal of Pharmacology and Experimental Therapeutics·Arvinder K DhallaLuiz Belardinelli
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Günter A MüllerTimo D Müller
Mar 2, 2021·Medicinal Research Reviews·Bruna C GalgaroMárcia R Wink
Dec 29, 2020·Biochemical Pharmacology·Shanu Jain, Kenneth A Jacobson
Jun 25, 2021·Reviews in Endocrine & Metabolic Disorders·Olakunle Sanni, G Terre'Blanche

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