Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits

British Journal of Pharmacology
A Z El-HashimC P Page

Abstract

1. Recent work has suggested that adenosine may be involved in asthma via the activation of A1 receptors. However, the role of the recently cloned A3 receptor in airways is largely unknown. In the present study, we have investigated the role of the A3 receptor in adenosine-induced bronchoconstriction in allergic rabbits. 2. Aerosol challenge of antigen (Ag) immunized rabbits with the adenosine precursor, adenosine 5'-monophosphate (AMP), resulted in a dose-dependent fall in dynamic compliance (Cdyn). The maximum fall in Cdyn in these rabbits was significantly greater than that in litter matched, sham immunized animals (P < 0.05). However, there was no significant difference in the maximum increase in airways resistance (Rt) between Ag and sham immunized rabbits (P > 0.05). 3. Aerosol challenge of Ag immunized rabbits with cyclopentyl-adenosine (CPA) (A1-receptor agonist) elicited a dose-dependent fall in Cdyn in Ag immunized rabbits and the maximum fall in Cdyn in these rabbits was significantly greater than that observed in sham immunized rabbits (P < 0.05). Similarly, CPA induced dose-dependent increases in R1 in Ag immunized rabbits whereas sham immunized rabbits failed to respond to CPA within the same dose range. The maxim...Continue Reading

References

Nov 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q Y ZhouO Civelli
Feb 7, 1992·Journal of Medicinal Chemistry·K A JacobsonM Williams
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Jan 21, 1986·European Journal of Pharmacology·L E GustafssonB Cederqvist
Jan 1, 1989·Pulmonary Pharmacology·R PolosaM K Church
Apr 1, 1988·British Journal of Pharmacology·K A Lundblad, C G Persson
Aug 1, 1972·The Journal of Physiology·B L Ginsborg, G D Hirst
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C LondosJ Wolff
Jul 1, 1982·British Journal of Pharmacology·C M Brown, M G Collis
Feb 1, 1983·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Jul 1, 1995·British Journal of Pharmacology·J P HannonJ R Fozard
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·R PolosaA Mistretta
Dec 1, 1993·Journal of Pharmacological and Toxicological Methods·E M MinshallC P Page
Jan 1, 1994·Trends in Pharmacological Sciences·J A Ribeiro, A M Sebastião
Oct 1, 1993·Trends in Pharmacological Sciences·M G Collis, S M Hourani
Mar 18, 1996·European Journal of Pharmacology·J R FozardH J Schuurman

❮ Previous
Next ❯

Citations

Jul 4, 1998·Trends in Pharmacological Sciences·K A Jacobson
Apr 2, 1999·Trends in Pharmacological Sciences·J W Nyce
Nov 11, 1999·Drug Discovery Today·S M Kaiser, R J Quinn
May 22, 2002·Current Opinion in Pharmacology·Domenico Spina, Clive P Page
Nov 2, 2002·British Journal of Pharmacology·Timothy J Martin, Kenneth J Broadley
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J R Fozard, J P Hannon
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M Spruntulis, K J Broadley
Aug 7, 2002·Antisense & Nucleic Acid Drug Development·Anthony SandrasagraJonathan W Nyce
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Domenico Spina
Jan 25, 2005·Acta Pharmacologica Sinica·Wan-Chun SunXing-Zu Zhu
May 9, 2013·BioMed Research International·Nurfatin Asyikhin KamaruzamanBadrul Hisham Yahaya
Sep 25, 2012·European Journal of Pharmacology·Alessio AlfieriCarla Cicala
Apr 24, 2008·Pulmonary Pharmacology & Therapeutics·Sandra Keir, Clive Page
Nov 22, 2007·Pharmacology & Therapeutics·Stefania GessiPier Andrea Borea
Jan 25, 2006·British Journal of Pharmacology·Sandra KeirClive Page
Feb 7, 2006·European Journal of Pharmacology·Lucia SpicuzzaRiccardo Polosa
May 7, 2013·Expert Opinion on Therapeutic Targets·Massimo CarusoRiccardo Polosa
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·H J PatelC P Page
Jul 16, 2013·European Journal of Pharmacology·Carla Cicala, Armando Ialenti
Feb 2, 2006·Fundamental & Clinical Pharmacology·Cristina RussoRiccardo Polosa
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M G Matera, R Polosa
Jul 7, 2017·Medicinal Research Reviews·Kenneth A JacobsonStefania Gessi
Jul 27, 2007·Platelets·K N Kornerup, C P Page
Jan 5, 2005·The Journal of Clinical Investigation·Chun-Xiao SunMichael R Blackburn
Jun 1, 2008·Expert Review of Respiratory Medicine·Yonca Nuhoglu, Cagatay Nuhoglu
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Nov 13, 2014·Pharmacological Reviews·Pier Andrea BoreaStefania Gessi
May 22, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael R Blackburn
Nov 14, 1998·The American Journal of Physiology·W Abebe, S J Mustafa
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen L TilleyBeverly H Koller
May 20, 2003·Journal of Applied Physiology·Qihai GuLu-Yuan Lee
Jan 10, 2008·Chemical Reviews·Pier Giovanni BaraldiPier Andrea Borea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.