Characterization of alkylphosphonic acid vapors using atmospheric flow tube-ion trap mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Kelsey A Morrison, Brian H Clowers

Abstract

A key aspect of detecting hazardous compounds at ultra-trace levels for processing, compliance, and clean-up purposes involves developing methods that are not only sensitive, but also highly selective with minimal sampling effort. Atmospheric flow tube mass spectrometry (AFT-MS) using dielectric barrier discharge ionization has emerged as a technique that combines such features for vapor detection. AFT-MS is thus appealing for application to ambient screening for chemical warfare agents (CWAs) and their degradation products. Initial characterization of AFT-MS for CWA detection necessitates examining less harmful simulant species. A predominant hydrolysis product of most organophosphorus CWAs is methylphosphonic acid and most other hydrolysis products consist of some form of an alkylphosphonic acid. An application of AFT-MS is presented wherein a homologous series of four alkylphosphonic acids (methyl-, ethyl-, propyl-, and t-butylphosphonic acid) were first qualitatively evaluated as anionic clusters with nitrate. These anionic adducts were subsequently quantified from non-equilibrium headspace vapor sampled over alkylphosphonic acid solutions in methanol. The series of phosphonic acids demonstrated consistent relative ion abun...Continue Reading

References

Dec 10, 1999·Environmental Health Perspectives·N B MunroV Hauschild
Sep 7, 2001·International Journal of Mass Spectrometry and Ion Processes·R G EwingJ A Stone
Nov 5, 2002·Rapid Communications in Mass Spectrometry : RCM·Patrik SpanelDavid Smith
Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Dec 12, 2012·Analytical Chemistry·Robert G EwingBrian H Clowers
Oct 5, 2013·Analytical Chemistry·Robert G EwingDavid A Atkinson
Apr 4, 2014·The Analyst·Robert G EwingMarvin G Warner
Sep 10, 2015·Analytical Chemistry·Mosotho J GeorgeD Bradley G Williams

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