Characterization of altered patterns of endothelial progenitor cells in sickle cell disease related pulmonary arterial hypertension.

Pulmonary Circulation
Fatima AnjumRaj Wadgaonkar

Abstract

Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficient in EPCs, potentially contributing to endothelial dysfunction and disease progression. The number of circulating CD34+/CD14-/CD106+ EPCs was significantly lower in SCD patients with PAH than without PAH (P=0.025). CD34+/CD14-/CD106+ numbers significantly correlated with tricuspid regurgitation velocity (TRV, r=-0.44, P=0.033) 6-minute walk distance (6MWD, r= 0.72, P=0.001), mean pulmonary artery pressure (mPAP, r= -0.43, P=0.05), and pulmonary vascular resistance (PVR, r=-0.45, P=0.05). Other EPC subsets including CD31+/CD133+/CD146+ were similar between both groups. Numbers of EPCs did not correlate with age, sex, hemoglobin, WBC count, reticulocyte count, lactate dehydrogenase (LDH), iron/ferritin levels, and serum creatinine. These data indicate that subsets of EPC are lower in SCD patients with PAH than in those without PAH. Fewer EPCs in PAH patients may contribute to the pulmonary vascular pathology. Reduce...Continue Reading

Associated Clinical Trials

References

Sep 15, 1994·The American Journal of Cardiology·L L SuttonJ F Lewis
Aug 8, 2001·The Journal of Clinical Investigation·S DimmelerA M Zeiher
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mihail HristovPeter C Weber
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Neil J DavieKurt R Stenmark
Sep 4, 2003·The European Respiratory Journal·P DorfmüllerM Humbert
Dec 31, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jin HurYoung-Bae Park
Jan 22, 2004·Circulation·Rohit BudhirajaPaul M Hassoun
Jan 22, 2005·Annual Review of Medicine·Aarif Y Khakoo, Toren Finkel
Oct 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Víctor I PeinadoJoan A Barberà
Dec 3, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nikos Werner, Georg Nickenig
Feb 16, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aaron LiewTimothy O'Brien
Jun 15, 2007·Trends in Immunology·Isabelle PetitShahin Rafii
Sep 21, 2007·American Journal of Respiratory and Critical Care Medicine·Gian Paolo FadiniCarlo Agostini
Jan 22, 2008·Pulmonary Pharmacology & Therapeutics·Daniel J Weiss
Feb 9, 2008·The American Journal of Pathology·Kewal AsosinghSerpil C Erzurum
Mar 20, 2008·Cardiovascular Research·Anna ZampetakiQingbo Xu
Apr 10, 2009·Blood Cells, Molecules & Diseases·Michiel H StrijbosUNKNOWN CURAMA study group
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Mark ToshnerNicholas W Morrell

❮ Previous
Next ❯

Citations

Apr 1, 2014·Heart, Lung & Circulation·Haiying ChenLe-Xin Wang
Sep 10, 2013·Pulmonary Circulation·Maria RodrigoGregory J Kato
Apr 10, 2015·British Journal of Haematology·Melissa C CaugheyAlan L Hinderliter
Dec 6, 2017·Pulmonary Circulation·G RuffenachF Perros
Apr 23, 2016·The European Respiratory Journal·Vasile ForisHorst Olschewski
Sep 10, 2013·Pulmonary Circulation·Raj Wadgaonkar, Fatima Anjum
Jan 9, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ryota HashimotoSachin A Gupte

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

SAS
Cell
Quest

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.