Characterization of amyloid beta protein species in the plasma, cerebrospinal fluid and brains of patients with Alzheimer's disease

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
A Tamaoka

Abstract

Extracellular deposition of amyloid beta protein (A beta) as senile plaques and cerebral amyloid angiopathy (CAA) is one of the essential pathological characteristics of Alzheimer's disease (AD). Several A beta species with different carboxyl termini, including A beta 42 (43) and A beta 40 ending at residue 42 (43) and 40, respectively, have been identified in CAA and in senile plaque cores. Because A beta 42 (43), the major component of diffuse plaque which is the earliest pathological change in AD brains, forms insoluble amyloid fibrils more rapidly than does A beta 40, it has been hypothesized that A beta 42 (43) plays a role in amyloid seeding and A beta 40, in the elongation of amyloid fibrils on a seed of A beta 42 (43). We used enzyme-linked immunosorbent assay (ELISA) with site-specific monoclonal antibodies to differentiate A beta 42 (43) from A beta 40. First, we measured the amounts of different A beta species in plasma from patients with sporadic probable AD, age-matched patients with neurologic diseases but without dementia, and age-matched normal controls. Concentrations of A beta 1-40 and A beta 1-42 (43) in plasma did not differ significantly among the three groups. Second, CSF levels of A beta species (CSF-A be...Continue Reading

Citations

Oct 15, 2013·Biochimica Et Biophysica Acta·Aaron M SwomleyD Allan Butterfield
Feb 25, 2005·The Journal of Biological Chemistry·Robert D MoirRudolph E Tanzi
Jul 25, 2017·Neurology and Therapy·Ni-Chung LeeWuh-Liang Hwu
Feb 9, 2021·Reviews in the Neurosciences·Asiamah Ernest AmponsahHuixian Cui

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