PMID: 2121298Oct 1, 1990Paper

Characterization of an acute T lymphoblastic leukemia expressing the gamma/delta T-cell receptor

Blut
M Wilhelm, H P Tony

Abstract

Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the gamma/delta receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a "natural killer"-like activity can be induced in these cells by IL-2.

References

Jun 1, 1989·Immunology Today·F Triebel, T Hercend
Apr 1, 1989·European Journal of Immunology·J Nikolić-ZugićM J Bevan
Aug 1, 1988·Immunological Reviews·H R MacDonaldD H Raulet
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A WeissD Crommie
Aug 1, 1988·The Journal of Experimental Medicine·F HochstenbachJ G Seidman
Jan 1, 1988·Annual Review of Immunology·H von Boehmer
Jul 10, 1986·Nature·M B BrennerM S Krangel
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.