PMID: 2494659Mar 1, 1989Paper

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate

Proceedings of the National Academy of Sciences of the United States of America
D SchubertG Cole

Abstract

A secreted form of the amyloid beta protein precursor was isolated from the growth conditioned medium of the PC12 sympathetic nerve-like cell line. This protein is recognized by an antiserum that detects a protein of 140 kDa and a less abundant species of 115 kDa on NaDodSO4/acrylamide gels. The amyloid precursor proteins contain O-linked sugars and tyrosine sulfate and bind to the glycosaminoglycan heparin. These results suggest a role for extracellular sulfated glycoproteins in the pathogenesis of Alzheimer disease.

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Citations

Jan 1, 1991·Journal of Neuroscience Research·K C BreenB H Anderton
Apr 1, 1991·Journal of Neuroscience Research·P E FraserD A Kirschner
Oct 1, 1992·Journal of Neuroscience Research·K SambamurtiN K Robakis
Apr 15, 1994·Journal of Neuroscience Research·D K LahiriM R Farlow
Mar 1, 1994·Metabolic Brain Disease·A LeBlanc
Jan 1, 1991·Molecular Neurobiology·R N MartinsC L Masters
Jul 16, 1990·Biochemical and Biophysical Research Communications·G M ColeT Saitoh
Apr 29, 1994·Biochemical Pharmacology·W H LinJ A Roth
Oct 1, 1993·Clinical Biochemistry·P E FraserD R McLachlan
Jun 1, 1990·Journal of the Neurological Sciences·F KametaniT Ishii
Jan 1, 1992·Pharmacology & Therapeutics·A I BushC L Masters
Sep 1, 1994·Neuroscience Research·A OohiraF Matsui
Sep 1, 1989·Neurobiology of Aging·B Cordell
Sep 1, 1989·Neurobiology of Aging·R U Margolis, R K Margolis
Mar 1, 1991·Neurobiology of Aging·G M ColeT Saitoh
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·X H ZhaoL K Duffy
Sep 1, 1993·General Pharmacology·E Brandan, N C Inestrosa
Nov 25, 1997·Brain Research. Brain Research Reviews·M R Roberson, L E Harrell
Jul 27, 2001·Brain Research Bulletin·D StrausakG Multhaup
Nov 25, 1998·British Journal of Haematology·A HenryR Cappai
Apr 24, 1999·Neuropathology and Applied Neurobiology·E Storey, R Cappai
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R PalmertS G Younkin
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E H KooD L Price

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