Characterization of an androgen response element within the promoter of the epididymis-specific murine glutathione peroxidase 5 gene

Molecular and Cellular Endocrinology
Jean-Jacques LareyreJoël Drevet

Abstract

We have shown in earlier studies, using a mouse model, that the expression of the glutathione peroxidase 5 protein (GPX5) is restricted to the epididymis and that the accumulation of its corresponding mRNA is hormonally, spatially and temporally regulated throughout postnatal development. We report here, using run-on assays, transient expression experiments as well as gel-shift and footprinting analyses on the findings that at least part of the androgenic control of the GPX5 expression is exerted at the transcriptional level via an androgen response element localized in the distal promoter region of the GPX5 gene. The gpx5 androgen response element (ARE) is found to be consistent with the consensus palindromic steroid-receptor target sequence 5'-AGWACWnnnTGTYCT-3' but exhibits a quite weak conservation in the left half site. The data presented here further expand the diversity of sequence able to confer androgen responsiveness.

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Citations

Apr 28, 2004·Molecular and Cellular Endocrinology·Kichiya SuzukiMarie-Claire Orgebin-Crist
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·F ClaessensW Rombauts
Jun 24, 2000·Proceedings of the Society for Experimental Biology and Medicine·S S KoideM Kamada
Feb 28, 2003·Biology of Reproduction·Jérôme Lapointe, Jean-François Bilodeau
Mar 7, 2014·Molecular Reproduction and Development·Lihua YangYaoting Gui
Jan 18, 2006·Molecular and Cellular Endocrinology·Jin-Song ZhangYong-Lian Zhang
Sep 9, 2004·Molecular and Cellular Endocrinology·A BritanJ R Drevet
Jul 19, 2013·Biology of Reproduction·Lisha MouYaoting Gui
Jun 11, 2019·PloS One·Ludwig StenzAriane Paoloni-Giacobino
Aug 21, 2013·The Journal of Biological Chemistry·Wubin MaYonglian Zhang
Mar 23, 2010·Molecular Endocrinology·Sarah DenayerFrank Claessens
Aug 21, 2019·In Vitro Cellular & Developmental Biology. Animal·Zhaojin LuanJiaxin Zhang

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