Dec 1, 1995

Characterization of an anterior circulation rat subarachnoid hemorrhage model

Stroke; a Journal of Cerebral Circulation
A PiepgrasP Schmiedek


Our aim was to demonstrate the feasibility of an angiographically controlled rat model for the study of macrocirculatory and microcirculatory changes of the anterior intracranial circulation after subarachnoid hemorrhage. Subarachnoid hemorrhage was induced by transorbital injection of 0.3 mL of nonheparinized autologous arterial blood into the chiasmatic cistern. Changes in regional cerebral blood flow were continuously recorded with the use of laser-Doppler flowmetry over the parietal cortex. Angiographic verification of middle cerebral artery diameter was performed by carotid catheterization at baseline and 2 days after injection of blood or artificial cerebrospinal fluid. We monitored intracranial and systemic blood pressure during and after injections. Injection of artificial cerebrospinal fluid in the control group did not change the diameter of the middle cerebral artery. Injection of blood caused a significant arterial narrowing of 17.5%, from 0.37 +/- 0.04 mm to 0.31 +/- 0.04 mm after 2 days (P = .0001). In the control group regional cerebral blood flow decreased to 75.9 +/- 16.8% of preinjection control but quickly recovered to 99.7 +/- 19.4%. Intracranial pressure increased for 5 minutes after the injection to a maxi...Continue Reading

  • References19
  • Citations22


  • References19
  • Citations22


Mentioned in this Paper

Arterial Pulse Pressure
Cerebral Blood Flow Imaging
Subarachnoid Hemorrhage, Spontaneous
Cerebrospinal Fluid
Cerebral Angiography
Structure of Cisterna Chiasmatica
Cerebrovascular Circulation

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