Characterization of an attenuated total reflection-based sensor for integrated solid-phase extraction and infrared detection

Analytical Chemistry
M Carmen Alcudia-LeónMiguel Valcárcel

Abstract

A novel attenuated total reflection (ATR) sensor, which integrates solid-phase extraction (SPE) and infrared detection, is presented. The flow cell, which enables the on-line coupling with a sequential injection system, is the core of the proposed sensor since it allows the continuous delivery of different solutions through the ATR and also the continuous spectrum acquisition. A SPE sorbent material (LiChrolut EN) was located in the sensitive element of the ATR without using any external coating substance, increasing the versatility of the system. A marked sensitivity enhancement was obtained as the analyte was concentrated before detection. The new sensor was qualitatively and quantitatively validated using the determination of caffeine in soft drinks as the model analytical problem. Linearity, precision (RSD = 4%), and sensitivity (LOD = 7 microg/mL) levels have been established. Finally, the main advantages and limitations of the new proposal are presented and compared with existing alternatives.

References

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Citations

Jul 29, 2010·Analytical and Bioanalytical Chemistry·Ana GonzálvezMiguel de la Guardia
Mar 17, 2010·Analytica Chimica Acta·Shiro Matsuoka, Kazuhisa Yoshimura
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian W Huck
Oct 3, 2009·Applied Spectroscopy·David Pérez-PalaciosBernhard Lendl
Dec 12, 2017·ChemistryOpen·Meng LiTony D James
Jan 1, 2011·Analytical Methods : Advancing Methods and Applications·Ana GonzalvezSergio Armenta

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