PMID: 9161880Mar 1, 1997Paper

Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone

Immunology Letters
F BuseyneY Rivière

Abstract

A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 allele are able to present the peptide to the cytotoxic clone, but with reduced efficiency. Other B-cell lines, that have been genotyped as HLA-Cw0401+ were unable to present the peptide to the clone, suggesting the existence of other variants of HLA-Cw0401 or a loss of cell surface expression of this molecule.

References

Oct 1, 1992·The Journal of Experimental Medicine·J Zemmour, P Parham
Jun 1, 1995·The Journal of Experimental Medicine·J A McCutcheonP Parham
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K FalkH G Rammensee
Dec 1, 1996·Tissue Antigens·C VilchesM Kreisler
May 12, 2010·Molecular and Cellular Biology·Xiaowen HeShaohua Li

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Citations

May 11, 2012·Retrovirology·Donato Zipeto, Alberto Beretta
Aug 21, 2007·Immunome Research·Joo Chuan TongShoba Ranganathan
Sep 18, 2016·Protein & Cell·Xiaolong LiJia-Huai Wang
Jul 19, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Steffanie SabbajPaul A Goepfert

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