Jan 1, 1986

Characterization of an idiotype-binding helper cell required for the formation of timothy grass pollen antigen-B-specific IgE

International Archives of Allergy and Applied Immunology
A Malley

Abstract

Experiments were conducted using an excess of biosynthetically labeled timothy grass pollen antigen-B-specific (AgB-specific) T helper factor (THF) with enriched T cells, enriched B cells, or normal spleen cells to determine the site of the THF action. These studies indicated that the labeled THF bound preferentially to T cells, and analysis of the cell surface characteristics suggested that these T cells were Lyt 123+ cells. A panning technique using partially purified AgB-specific THF-coated Petri dishes depleted a population of idiotype-binding T cells that appears to be required for the formation of AgB-specific IgE antibody.

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Mentioned in this Paper

T-Lymphocyte
Timothy grass pollen
Spleen
Binding Sites, Antibody
Interleukin-1
Antigenic Specificity
Allergens
B-Lymphocytes
Antigens
Helper-Inducer T-Lymphocyte

About this Paper

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