Characterization of an insecticidal coumarin from Boenninghausenia albiflora

Phytotherapy Research : PTR
Rajnikant SharmaSimon Gibbons

Abstract

The leaves of Boenninghausenia albiflora afforded an insecticidal coumarin which was identified as murraxocin (7-methoxy-8-[1'-ethoxy-2'-hydroxy-3'-methyl-but-3'enyl]-coumarin) (1), on the basis of extensive 1- and 2-dimensional NMR experiments. This compound has previously been isolated from Murraya exotica but this is the first report of the full (1)H and (13)C data for this compound. This natural product was evaluated against important forest insect pests and was active against Plecoptera reflexa, Clostera cupreata and Crypsiptya coclesalis at different concentrations varying from 1.0% to 5% w/v. In the crude extract 70% mortality was observed, and for compound 1 80% mortality was observed at a concentration of 1.0% w/v. The percentage of insect mortality increased in a dose-dependent manner. Coumarins are poorly studied insecticides and there is potential to exploit this chemically simple group of natural products.

References

May 22, 1990·Biochimica Et Biophysica Acta·F N KoC M Teng
Nov 15, 2000·Fitoterapia·H A Oketch-RabahE K Mberu
Oct 1, 1992·Journal of Chemical Ecology·P EscoubasJ Mizutani

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Citations

Nov 25, 2011·Natural Product Research·Rajendra C PadaliaChandan S Chanotiya
Jan 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed Mohammed AlJabrHassan Al-Ayedh
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiqi ZhouKeWei Wang
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Bishnu JoshiWalter Luyten

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