Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta

The Journal of Clinical Endocrinology and Metabolism
M V St-PierreT Stallmach

Abstract

Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates. We investigated whether members of the OATP gene family could mediate fetal-maternal transfer of anionic steroid conjugates in the human placenta. OATP-B (gene symbol SLC21A9) was isolated from a placenta cDNA library. An antiserum to OATP-B detected an 85-kDa protein in basal but not apical syncytiotrophoblast membranes. Immunohistochemistry of first-, second-, and third-trimester placenta showed staining in the cytotrophoblast membranes and at the basal surface of the syncytiotrophoblast. Trophoblasts that reacted with an antibody to Ki-67, a proliferation-associated antigen, expressed lower levels of OATP-B. OATP-B mRNA levels were measured in isolated trophoblasts under culture conditions that promoted syncytia formation. Real-time quantitative PCR estimated an 8-fold increase in OATP-B expression on differentiation to syncytia. The uptake of [(3)H]estrone-3-sulfate, a substrate for OATP-B, was measured in basal syncytiotrophoblast membrane vesicles. Transport was saturable and partially inhibited by pregneno...Continue Reading

References

Jan 1, 1990·Progress in Neurobiology·P J Harrison, R C Pearson
Jan 29, 1990·Biochimica Et Biophysica Acta·Y Kudo, C A Boyd
Jun 1, 1990·The Journal of Clinical Endocrinology and Metabolism·E C SalidoL J Shapiro
Mar 1, 1980·Archives of Toxicology·C LiddiardH Nau
Jul 25, 1996·Biochimica Et Biophysica Acta·A S RoqueV Ganapathy
Jan 23, 1999·American Journal of Obstetrics and Gynecology·M T AcromiteL G Dorey
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J KönigD Keppler
Feb 29, 2000·Placenta·N P Illsley
Mar 30, 2000·American Journal of Obstetrics and Gynecology·D M StamilioG A Macones
May 3, 2000·The Journal of Clinical Investigation·G F SullivanW N Hait
Jun 30, 2000·Biochemical and Biophysical Research Communications·I TamaiA Tsuji
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·S LuisiA R Genazzani
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M V St-PierreJ J Marin
Feb 7, 2001·Pediatric Research·T Jansson

❮ Previous
Next ❯

Citations

Nov 20, 2009·Archives of Gynecology and Obstetrics·Valeria FeinshteinZvi Ben-Zvi
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik PacyniakGrace L Guo
Jun 21, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lauren M AleksunesCurtis D Klaassen
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Jan 25, 2013·Pharmacological Reviews·Patrick T Ronaldson, Thomas P Davis
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Tomohide KitanoEmi Nakashima
Feb 21, 2009·World Journal of Gastroenterology : WJG·Rocio I R MaciasMaria A Serrano
Aug 23, 2011·Annual Review of Pharmacology and Toxicology·Amanda ObaidatBruno Hagenbuch
Feb 13, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kathleen KöckKim L R Brouwer
Nov 25, 2011·Expert Review of Clinical Pharmacology·Anna KoenenHenriette E Meyer zu Schwabedissen
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Jan 21, 2011·Expert Opinion on Drug Metabolism & Toxicology·Erika K Pollex, Janine R Hutson
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Denis EvseenkoJeffrey A Keelan
Mar 5, 2015·The AAPS Journal·Nilay ThakkarWooin Lee
Mar 20, 2013·Molecular Aspects of Medicine·Bruno Hagenbuch, Bruno Stieger
May 21, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mea Melissa RahiKari Petri Laine
Mar 10, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ragia H GhoneimMicheline Piquette-Miller
May 17, 2017·Molecular Aspects of Medicine·Saraid McIlvrideCatherine Williamson
Feb 14, 2017·Drug Metabolism and Pharmacokinetics·Ayuko KondoKen Iseki
Sep 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M V St-PierreP J Meier
Oct 28, 2014·Environmental Toxicology·Gordon C DouglasElizabeth D Hilborn
Mar 15, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Jose J G MarinMaria A Serrano
Dec 17, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fabio QuondamatteoBirgitta C Burckhardt
Dec 31, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fumi KatohGreg G Goss
Apr 15, 2004·American Journal of Physiology. Renal Physiology·Snezana PetrovicManoocher Soleimani
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Jie XuManoocher Soleimani
Apr 9, 2005·American Journal of Physiology. Cell Physiology·Teresa ShermanKeith Nehrke
Dec 3, 2004·American Journal of Physiology. Cell Physiology·Zhaohui WangManoocher Soleimani
Apr 9, 2004·American Journal of Physiology. Cell Physiology·Ralf R Regeer, Daniel Markovich
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Hagenbuch, C Gui
Aug 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Fanfan ZhouGuofeng You
Nov 15, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Katherine S FennerHugh A Barton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.