Characterization of anacardic acids by micellar electrokinetic chromatography and mass spectrometry

Journal of Chromatography. a
Petr CeslaPavel Jandera

Abstract

A possibility of using capillary electrophoresis for separation of anacardic acids (6-alkylsalicylic acids) has been studied. Conventional micellar electrokinetic chromatography (MEKC) in non-coated fused silica capillaries and reversed-flow micellar electrokinetic chromatography (RF-MEKC) in capillaries coated with polydimethylacrylamide was applied for separation of anacardic acids extracted from cashew nuts. Influence of the composition of background electrolyte on the resolution of anacardic acid isomers was evaluated. Separations were performed using sodium dodecyl sulphate (SDS) micelles and mixed micelles of SDS and polyoxyethylene lauryl ether as a pseudostationary phase. To further improve the separation in RF-MEKC, beta-cyclodextrin and a dual cyclodextrin system of beta-cyclodextrin with heptakis-6-sulphato-beta-cyclodextrin was added to the working electrolyte. Best separation of anacardic acids were achieved in the polydimethylacrylamide-coated capillary using 10 mM phosphate background electrolyte pH 6.5 with addition of 1 M urea, 20% acetonitrile, 10 mM of beta-cyclodextrin and 1 mM of heptakis-6-sulfo-beta-cyclodextrin. Mass spectrometry was used for the identification of anacardic acids in the extract from cash...Continue Reading

References

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Citations

Feb 28, 2007·The Journal of Antibiotics·Nahyun KimDongho Lee
Nov 17, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Toru Takahashi, Hitoshi Hoshino
Dec 25, 2010·Journal of Pharmaceutical and Biomedical Analysis·Roberto Gotti
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Elena Hurtado-FernándezAlberto Fernández-Gutiérrez
Jan 31, 2007·Journal of Mass Spectrometry : JMS
Oct 1, 2010·Electrophoresis·Serena OrlandiniSandra Furlanetto

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