PMID: 9179505Apr 14, 1997Paper

Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems

Drug and Alcohol Dependence
S P Welch

Abstract

The endogenous ligand for the cannabinoid receptor, arachidonylethanolamide (anandamide), has been shown to produce antinociception using the tail-flick test following intrathecal administration. Anandamide was administered i.p. (40 mg kg) to mice four times per day for 3 days. Tolerance developed to anandamide: the ED50 for anandamide (i.t.) was shifted from 40 (26-61) to 139 (79-248) micrograms/mouse. Anandamide-tolerant mice were cross-tolerant to delta 9-THC and CP55,940, but not cross-tolerant to mu-, delta- or kappa- opioids, including dynorphins. Conversely, delta 9-THC-tolerant mice are cross-tolerant to anandamide, CP55,940 and kappa agonists. Our data indicate that anandamide and delta 9-THC differ in the mechanisms by which they induce tolerance, in particular the interaction with endogenous dynorphinergic systems.

References

Jul 1, 1994·European Journal of Pharmacology·R PertweeR Mechoulam
Oct 18, 1994·Biochemical Pharmacology·R MechoulamB R Martin
Feb 9, 1993·European Journal of Pharmacology·E Fride, R Mechoulam
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderW A Devane
Jul 20, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·L S HARRIS

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Citations

Mar 3, 2005·European Journal of Pharmacology·Jenny L WileyWilliam L Dewey
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rafael Maldonado, Olga Valverde
Jan 7, 2004·Life Sciences·Diana L Cichewicz
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·Daniela ViganòDaniela Parolaro
May 28, 2005·Pharmacology, Biochemistry, and Behavior·Sara GonzálezJavier Fernández-Ruiz
Nov 27, 1998·European Journal of Pharmacology·R MechoulamV Di Marzo
Sep 24, 1999·European Journal of Pharmacology·D J MasonS P Welch
Aug 17, 2002·Pharmacology & Therapeutics·Rafael Maldonado
Jul 3, 1999·Trends in Pharmacological Sciences·J ManzanaresJ A Fuentes
Jan 9, 1999·Trends in Neurosciences·V Di MarzoL De Petrocellis
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
Jun 15, 1999·Progress in Neurobiology·A Ameri
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katherine W FalenskiLaura J Sim-Selley
May 17, 2008·Addiction Biology·Patricia RobledoRafael Maldonado
Feb 22, 2011·Neuroscience·R MaldonadoP Robledo
Jun 11, 2004·European Journal of Pharmacology·Melinda L Cox, Sandra P Welch
Aug 7, 2007·Neuropharmacology·Laura E WiseAron H Lichtman
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E Fride
Dec 7, 2002·Pain·L R GardellF Porreca

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