Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Mariam H M YousifIbrahim F Benter

Abstract

Although exogenous administration of Angiotensin-(1-7) [Ang-(1-7)] can prevent development of diabetes induced end-organ damage, little is known about the role of endogenous Ang-(1-7) in diabetes and requires further characterization. Here, we studied the effects of chronically inhibiting endogenous Ang-(1-7) formation with DX600, a selective angiotensin converting enzyme-2 (ACE2) inhibitor, on renal and cardiac NADPH oxidase (NOX) activity, vascular reactivity and cardiac function in a model of Type-1 diabetes. The contribution of endogenous Ang-(1-7) to the protective effects of Losartan and Captopril and that of prostaglandins to the cardiovascular effects of exogenous Ang-(1-7) were also examined. Cardiac and renal NOX activity, vascular reactivity to endothelin-1 (ET-1) and cardiac recovery from ischemia/reperfusion (I/R) injury were evaluated in streptozotocin-treated rats. Chronic treatment with DX600 exacerbated diabetes-induced increase in cardiac and renal NOX activity. Diabetes-induced abnormal vascular reactivity to ET-1 and cardiac dysfunction were improved by treatment with Ang-(1-7) and worsened by treatment with DX600 or A779, a Mas receptor antagonist. Ang-(1-7)-mediated improvement in cardiac recovery or vascu...Continue Reading

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Citations

Oct 4, 2012·Clinical and Experimental Pharmacology & Physiology·Hui-Yu YangZhi-Ming Yang
Nov 7, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Teng JiangYingdong Zhang
Mar 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna M PapinskaKathleen E Rodgers
Jun 16, 2015·British Journal of Pharmacology·A M PapinskaK E Rodgers
Dec 18, 2013·Clinical Science·Vaibhav B PatelGavin Y Oudit
Mar 19, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Teng JiangYing-Dong Zhang
Jan 24, 2014·Clinical Science·Fernando P DominiciJorge F Giani
Oct 19, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Aleksandar KibelInes Drenjancevic
Nov 28, 2013·Journal of Vascular Research·Ines Drenjancevic, Aleksandar Kibel
Apr 25, 2018·Clinical Science·Nathalia SengerMaria Luiza M Barreto-Chaves
Apr 16, 2016·Circulation Research·Vaibhav B PatelGavin Y Oudit
Oct 10, 2018·American Journal of Physiology. Endocrinology and Metabolism·Justin LoloiAmy C Arnold
Nov 11, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Amanda J Miller, Amy C Arnold
Aug 28, 2020·Frontiers in Cardiovascular Medicine·Annamaria MascoloAnnalisa Capuano
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhen-Jiang DingQin Li
Jun 5, 2020·Journal of Endocrinological Investigation·T Filardi, S Morano
Feb 28, 2018·International Journal of Molecular Medicine·Jianfang ChenJingfu Chen
Apr 2, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Andrew M SouthMark C Chappell
Jul 24, 2020·Journal of Drug Targeting·Saghir AkhtarAbdella M Habib
Jul 24, 2020·International Journal of Molecular Sciences·Amanda J MillerAmy C Arnold
May 8, 2021·Frontiers in Pharmacology·Annamaria MascoloAnnalisa Capuano
Oct 17, 2021·Molecular and Cellular Biochemistry·Santoshi SahuRamesh K Goyal

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