Characterization of angiotensin-(1-7) in the urine of normal and essential hypertensive subjects

American Journal of Hypertension
C M FerrarioM Luque

Abstract

A total of 31 healthy volunteers [39 +/- 7 (SD) years] and 18 untreated essential hypertensive subjects [43 +/- 9 years] collected urine for 24 h after a physical examination and laboratory tests. Radioimmunoassay measurements of angiotensin-(1-7) [Ang-(1-7)] in urine and plasma were done as described previously. Sitting systolic and diastolic blood pressures (+/- SD) averaged 118 +/- 11/74 +/- 7 mm Hg and 146 +/- 16/96 +/- 8 mm Hg in normal and essential hypertensive subjects, respectively (P < .001), whereas 24 h urinary volume was not different in normal and essential hypertensive subjects (P > .05). The concentration of Ang-(1-7) in the urine of normal subjects averaged 62.6 +/- 22.6 pmol/L corresponding to a urinary excretion rate of 98.9 +/- 44.7 pmol/24 h. Concurrent measurements of plasma Ang-(1-7) showed that the content of Ang-(1-7) in urine was 2.5-fold higher than that measured in the plasma. In contrast, untreated essential hypertensive subjects had lower concentrations and 24 h urinary excretion rates of Ang-(1-7) averaging 39.4 +/- 18.0 pmol/L and 60.2 +/- 14.6 pmol/24 h, respectively, (P < .001). Differences in the excretory rate of Ang-(1-7) between normal volunteers and essential hypertensive subjects were not...Continue Reading

Citations

Jul 17, 1999·The American Journal of Physiology·R K Handa
Jun 21, 2002·American Journal of Hypertension·Carlos M FerrarioClarence E Grim
Apr 6, 2006·Hypertension·Khalid M ElasedMariana Morris
Apr 26, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jasmina VaragicCarlos M Ferrario
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rui YangAlain G Dupont
May 30, 2012·Clinical Science·Danielle Zimmerman, Kevin D Burns
Apr 21, 2012·International Journal of Hypertension·Sergio Veloso Brant Pinheiro, Ana Cristina Simões E Silva
Mar 16, 2013·British Journal of Pharmacology·A C Simões e SilvaM M Teixeira
Oct 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Sean E ThatcherLisa A Cassis
Jun 18, 2015·Therapeutic Advances in Cardiovascular Disease·Peng ZhouHeng-Jie Cheng
Aug 2, 2017·The Open Ophthalmology Journal·Mervi HolappaAnu Vaajanen
Nov 11, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Amanda J Miller, Amy C Arnold
Jan 1, 2003·Letters in Peptide Science : LIPS·Fiona J WarnerAnthony J Turner
Aug 24, 1999·Hypertension·A J RoksW H van Gilst
May 25, 2002·Canadian Journal of Physiology and Pharmacology·Anthony J TurnerNigel M Hooper
Mar 8, 2003·Hypertension·Christos TikellisMark E Cooper
Jul 7, 2007·Cardiovascular Drug Reviews·Aaron J Trask, Carlos M Ferrario
Apr 23, 2010·Journal of Hypertension·Maria Paz OcaranzaMario Chiong
Mar 26, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Zhen TanHong Ma
Feb 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Damian H CohallCarlos M Ferrario
Apr 17, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lisa K WashburnT Michael O'Shea
Dec 7, 2014·American Journal of Hypertension·Michel E SafarAlbert Mimran
Jan 1, 2003·Letters in Peptide Science : LIPS·Fiona J WarnerAnthony J Turner
Apr 23, 2020·Endocrine·K Bridget BrosnihanBrian Westwood
Apr 9, 2010·American Journal of Physiology. Renal Physiology·Carlos M Ferrario, Jasmina Varagic
Nov 4, 2010·Current Opinion in Nephrology and Hypertension·Carlos M Ferrario
Oct 25, 2012·The Journal of Endocrinology·Robson A S SantosMichael Bader
Oct 18, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Mark C Chappell
Nov 28, 2013·Therapeutic Advances in Cardiovascular Disease·Carlos M FerrarioRonald D Smith
Oct 12, 2019·American Journal of Hypertension·Daniela Medina, Amy C Arnold
Nov 4, 2000·Expert Opinion on Investigational Drugs·R Komers, K Komersova
Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ana Cristina Simões E Silva, Joseph T Flynn
Oct 19, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Amy C ArnoldDebra I Diz
Aug 21, 2019·Nature Reviews. Cardiology·Maria Paz OcaranzaSergio Lavandero
Feb 25, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Damian CohallMarcella Nunez-Smith
Jan 29, 2020·Heliyon·Daniel Massote MagalhãesAna Cristina Simões E Silva
Apr 3, 2021·Molecular and Cellular Endocrinology·Sarfaraz AhmadCarlos M Ferrario

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