Characterization of anisotropic T2W signals from human knee femoral cartilage: The magic angle effect on a spherical surface.

NMR in Biomedicine
Yuxi Pang

Abstract

The aim of the current study was to propose a generalized magic angle effect (gMAE) function for characterizing anisotropic T2W signals of human knee femoral cartilage with a spherical surface in clinical studies. A gMAE model function f(α, ε) was formulated for an orientation-dependent (ε) transverse T2 (i.e., 1/R2 ) relaxation in cartilage assuming an axially symmetric distribution (α) of collagen fibers. T2W sagittal images were acquired on an adult volunteer's healthy knee at 3 T, and ROI-based average signals S(ε) were extracted from angularly and radially segmented femoral cartilage. Compared with the standard MAE (sMAE) functions in the deep (DZ, α = 0°) and in the superficial (SZ, α = 90°) zones, a general form of R2 orientation-dependent function f(α, ε) was fitted to S(ε), including an isotropic R2 contribution (internal reference [REF]). Goodness of fit was evaluated by root-mean-square deviations (RMSDs). An F-test and a paired t-test were respectively used to assess significant differences between the observed variances and means, with statistical significance set to p less than .05. As a symmetric orientation-dependence function with a varying dynamic range, the proposed gMAE model outperformed the previous sMAE f...Continue Reading

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