PMID: 9529079Apr 7, 1998Paper

Characterization of anticapsular monoclonal antibodies that regulate activation of the complement system by the Cryptococcus neoformans capsule

Infection and Immunity
T R KozelK K Wall

Abstract

Incubation of the encapsulated yeast Cryptococcus neoformans in human serum leads to alternative pathway-mediated deposition of C3 fragments in the capsule. We examined the ability of monoclonal antibodies (MAbs) specific for different epitopes of the major capsular polysaccharide to alter the kinetics for classical and alternative pathway-mediated deposition of C3 onto a serotype A strain. We studied MAbs reactive with capsular serotypes A, B, C, and D (MAb group II); serotypes A, B, and D (MAb group III); and serotypes A and D (MAb group IV). The MAb groupings are based on antibody variable region usage which determines the antibody molecular structure. When both the classical and alternative pathways were operative, group II MAbs induced early classical pathway-mediated binding of C3 but reduced the overall rate of C3 accumulation and the amount of bound C3. Group III MAbs closely mimicked the effects of group II MAbs but exhibited reduced support of early classical pathway-facilitated accumulation of C3. Depending on the antibody isotype, group IV MAbs slightly or markedly enhanced early binding of C3 but had no effect on either the rate of C3 accumulation or the amount of bound C3. When the classical pathway was blocked, g...Continue Reading

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Citations

May 19, 2000·Infection and Immunity·M FeldmesserA Casadevall
Oct 12, 2011·Immunological Investigations·Michael S Price, John R Perfect
Oct 27, 2010·PLoS Neglected Tropical Diseases·Livia C L LopesEliana Barreto-Bergter
Nov 15, 2007·Current Infectious Disease Reports·Helene C EisenmanErin E McClelland
Sep 24, 2005·Infection and Immunity·Luis R Martinez, Arturo Casadevall
Dec 25, 2004·Infection and Immunity·Ryan M KellyStuart M Levitz
Aug 28, 1998·Research in Immunology·T R Kozel

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