Characterization of Antimicrobial Susceptibility and Its Association with Virulence Genes Related to Adherence, Invasion, and Cytotoxicity in Campylobacter jejuni and Campylobacter coli Isolates from Animals, Meat, and Humans

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Lisette LapierreRoberto Vidal

Abstract

The aim of this research was to statistically analyze the association between antimicrobial susceptibility/resistance to erythromycine, gentamicin, ciprofloxacin, and tetracycline and 11 virulence genes associated with adherence, invasion, and cytotoxicity in 528 isolates of Campylobacter coli and Campylobacter jejuni obtained from retail meat and fecal samples from food-producing animals and human patients. A high percentage of Campylobacter strains were resistant to antimicrobials, specifically ciprofloxacin and tetracycline. Moreover, we observed a wide distribution of virulence genes within the analyzed strains. C. jejuni strains were more susceptible to antimicrobials, and showed greater number of virulence genes than C. coli strains. Genes related to invasion capability, such as racR, ciaB, and pldA, were associated with antimicrobial-susceptible strains in both species. The genes cdtA and dnaJ, a citotoxin unit and an adherence-related gene, respectively, were associated with antimicrobial-resistant strains in both species. In conclusion, Campylobacter strains show a statistically significant association between antimicrobial susceptibility and the presence of virulence genes.

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Citations

Feb 9, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mojtaba RaeisiHesamaddin Shirzad-Aski
Dec 12, 2018·Canadian Journal of Microbiology·Mauricéia Greici de OliveiraWladimir Padilha da Silva
Jul 31, 2019·BioMed Research International·Arturo LevicanLorena Porte
Apr 6, 2020·Journal of Applied Microbiology·Orkun BabacanJanet E L Corry
Jun 7, 2017·The Onderstepoort Journal of Veterinary Research·Samantha Reddy, Oliver T Zishiri
Feb 23, 2021·Frontiers in Cellular and Infection Microbiology·Se-Hun KimDeog Hwan Oh
Aug 4, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Manel GharbiAbderrazek Maaroufi

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Datasets Mentioned

BETA
KF846052
KJ081742
CP000550
AF114831
CP006729
GQ491060
KJ15268

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Byotiper
Infostat
UPGMA
BLAST
BioNumerics GelCompar II

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