PMID: 11931577Apr 5, 2002Paper

Characterization of apolipoprotein E genetic variations in Taiwanese: association with coronary heart disease and plasma lipid levels

Human Biology
June Hsieh WuJau-Tsuen Kao

Abstract

Apolipoprotein E (apoE, protein; APOE, gene) is important in lipoprotein metabolism. Three isoforms, apoE2 (Cys112 Cys158), apoE3 (Cys112 Arg158), and apoE4 (Arg112 Arg158), are present in the general population. This report investigates the frequency distribution of apoE isoforms and the association of APOE genotypes with plasma lipid profile and coronary heart disease (CHD) in a population of Taiwan. ApoE isoforms were determined genetically by polymerase chain reaction and HhaI restriction enzyme digestion in control and coronary heart disease (CHD) patients. Plasma lipid and lipoprotein concentrations were also determined. The control group exhibited frequencies of 84.6% APOE3, 7.9% APOE4, 7.5% APOE2, 70.6% APOE3E3, 14.4% APOE3E4, 13.6% APOE2E3, and 1.4% APOE2E4. Comparable frequencies were observed in the CHD group. In both APOE2 carrier and APOE3E3 groups, the CHD patients expressed abnormal lipid profiles while the control group expressed normal lipid profiles. The APOE4 carriers, however, expressed abnormal lipid profiles in both normal control and CHD groups. Extremely high apoE levels in the hypertriglyceridemic group (TG > 400 mg/dL) seemed to be undesirable and were often observed in CHD patients.

Citations

Jul 20, 2006·Human Genomics·Victoria E H CarltonMalek Faham
Dec 29, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Sherif ArafaAdel Abdel-Ghaffar
Feb 21, 2003·Angiology·Genovefa KolovouDimitri P Mikhailidis
Jan 28, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jae-Young UmSeung-Heon Hong
Jun 6, 2006·Breast Cancer Research and Treatment·Shun-Jen ChangLi-Yu Tsai
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Jan 25, 2003·Current Opinion in Lipidology·Jose M Ordovas
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