Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test

The Analyst
Michael Philip BeestonRobert Fairhurst

Abstract

A new method is presented for the preparation, characterization and use of PbS (galena) nanoparticles within an in vitro bioaccessibility test representing the respiratory tract, specifically the conditions occurring in conjunction with phagocytosis by cells using artificial lysosomal fluid. Particle production through nanosecond laser ablation enables their rapid production with a relatively narrow particle size distribution, and a diameter enabling them to represent particles that can enter the alveolar region of the respiratory tract (<3 microm). The PbS nanoparticles were characterized by cascade impaction to define their particle size distribution and through the use of X-ray diffraction (XRD) and electron microprobe analysis (EMPA) to define their mineralogy and homogeneity respectively. The particles were collected via liquid impingement in artificial lysosomal fluid and the undissolved material was separated via ultrafiltration after a contact time of 7-140 hours to define the bioaccessibility. The particles produced by the laser ablation of PbS have a homogenous composition and are 0.083-0.75 microm in diameter, spherical, crystalline, and have the same stoichiometry as the target material. Despite the low solubility c...Continue Reading

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Citations

Mar 8, 2016·Ecotoxicology and Environmental Safety·Junxing YangXiaokun Han
Feb 27, 2015·Autophagy·Christophe MacriSylviane Muller
Apr 6, 2016·The Science of the Total Environment·Mohammed BaaloushaMichael F Hochella
Sep 16, 2019·The Science of the Total Environment·Rubina KhanamH Pathak
Mar 27, 2010·Environmental Science & Technology·Judith E S BarrettJohn M Charnock

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