Characterization of atenolol transformation products on light-activated TiO2 surface by high-performance liquid chromatography/high-resolution mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
C MedanaClaudio Baiocchi

Abstract

We have studied the photocatalytic transformation of atenolol, 4-[2-hydroxy-3-[(1-methyl)amino]propoxyl]benzeneacetamide, a cardioselective beta-blocking agent used to treat cardiac arrhythmias and hypertension, under simulated solar irradiation using titanium dioxide as photocatalyst. The investigation involved monitoring drug decomposition, identifying intermediate compounds, assessing mineralization, and evaluating toxicity. High-performance liquid chromatography (HPLC) coupled to high-resolution mass spectrometry (HRMS) via an electrospray ionization (ESI) interface was a powerful tool for the identification and measurement of the degradation products; 23 main species were identified. Intermediates were characterized through their chromatographic behavior and evolution kinetics, coupled with accurate mass information. Through the full analysis of MS and MS(n) spectra and a comparison with parent drug fragmentation pathways, the diverse isomers were characterized. Neither atenolol nor the intermediates formed exhibit acute toxicity. All intermediates are easily degraded and no compound identified could withstand 2 h irradiation. Photomineralization of the substrate in terms of carbon mineralization and nitrogen release was r...Continue Reading

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Citations

Mar 25, 2011·Environmental Science & Technology·Arne WickThomas A Ternes
Apr 24, 2012·Journal of Pharmaceutical and Biomedical Analysis·Saranjit SinghRavi P Shah
Feb 23, 2008·Journal of Pharmaceutical and Biomedical Analysis·P CalzaC Baiocchi
Sep 21, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Debora FabbriPaola Calza
Nov 6, 2018·Rapid Communications in Mass Spectrometry : RCM·Amanda V QuaresmaRobson J C F Afonso
Oct 23, 2009·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Alena Kubatova
Jul 10, 2021·Journal of Photochemistry and Photobiology. B, Biology·Alice PavanelloM Luisa Marin

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