Characterization of atherosclerotic plaques in human coronary arteries with 16-slice multidetector row computed tomography by analysis of attenuation profiles

Academic Radiology
Maximilian GalonskaFriedrich D Knollmann

Abstract

We investigated if 16-slice multidetector row computed tomography (MDCT) allows correct classification of coronary plaques into calcified or noncalcified and further subclassification of noncalcified plaques into either lipid-rich with a necrotic core or fibrous. Coronary arteries of 30 isolated hearts were filled postmortem with a contrast medium and scanned with a 16-slice MDCT imager (Light Speed 16 pro, GEMS, Milwaukee, WI). Imaging parameters: collimation 16 x 0.625 mm, pitch 0.325, tube voltage 120 kV, tube current 250 mA, and gantry rotation time 500 milliseconds. The images were reformatted perpendicular to the axis of the coronary arteries (AW 4.2 software, GEMS) and analyzed by establishing attenuation profiles of the coronary cross sections (ImageJ 1.33n software, NIH, Bethesda, MD). Results were compared with the correlating histopathologic sections of the arteries. Analysis of 195 CT cross-sections showed a sensitivity and specificity for the correct classification of calcified plaques of 100% and 97.3% and for noncalcified plaques of 80.8% and 95.1%, respectively. The attenuation of epicardial fat ranged from -119 Hounsfield units (HU) to 23 HU (median -71 HU), and from 93 HU to 625 HU (308 HU) for the contrast me...Continue Reading

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Citations

Apr 22, 2009·AJR. American Journal of Roentgenology·Pamela T JohnsonElliot K Fishman
Oct 30, 2009·Radiology·Gorka BastarrikaU Joseph Schoepf
Apr 22, 2011·The International Journal of Cardiovascular Imaging·Wisnumurti KristantoMatthijs Oudkerk
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Aug 14, 2010·Radiologic Clinics of North America·Elisabeth ArnoldiU Joseph Schoepf
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Feb 26, 2015·AJR. American Journal of Roentgenology·Farhood Saremi, Stephan Achenbach
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Feb 15, 2018·Korean Circulation Journal·Aeshita DwivediJames K Min
Dec 21, 2010·Expert Review of Cardiovascular Therapy·Markus WeiningerU Joseph Schoepf

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