PMID: 7370801May 26, 1980Paper

Characterization of benzodiazepine receptors in primary cultures of fetal mouse brain and spinal cord neurons

Brain Research
A HuangP Skolnick

Abstract

Primary cultures of fetal mouse brain and spinal cord were examined for the presence of binding sites for [3H]diazepam. Both brain and spinal cord cultures contain high affinity binding sites which resemble benzodiazepine receptors found in mammalian CNS with respect to both pharmacologic profile and response to exogenously applied GABA. These observations, coupled with the electrophysiologic properties of these cells suggest that primary cultures of fetal mouse brain and spinal cord may be valid models for studying the role and regulation of the benzodiazepine receptor.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Braestrup, R F Squires
Mar 15, 1978·European Journal of Pharmacology·R S Chang, S H Snyder
Jul 27, 1978·Nature·J F TallmanD W Gallager
Aug 15, 1978·European Journal of Pharmacology·G J WastekH I Yamamura
Nov 9, 1978·Life Sciences·M J WilliamsonP Skolnick
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T Asano, S Spector
Sep 24, 1979·Life Sciences·P J MarangosP Skolnick
Mar 1, 1979·Journal of Neurochemistry·P J Syapin, P Skolnick
Oct 12, 1978·Nature·M J WilliamsonP Skolnick
Apr 21, 1977·Nature·R F Squires, C Brastrup
Aug 1, 1978·Neuroscience Letters·C BraestrupA Schousboe
Sep 1, 1978·Neuroscience Letters·W E MüllerU Wollert

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Citations

Jul 15, 1983·Biochemical Pharmacology·D J FellerD B Bylund
May 18, 1984·European Journal of Pharmacology·J H Skerritt, R L Macdonald
Dec 1, 1987·European Journal of Pharmacology·J M MaloteauxA Trouet
Mar 22, 1988·European Journal of Pharmacology·L G MillerR I Shader
Jul 1, 1981·Brain Research·C R Walker, J H Peacock
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·L HertzJ S Richardson
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E MatthewD L Engelhardt
Oct 1, 1984·Journal of Neurochemistry·M M VoigtJ H Wyche
Dec 1, 1985·Journal of Neurochemistry·P J SyapinE P Noble
Jan 1, 1981·Medicinal Research Reviews·P Skolnick, S M Paul

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