Characterization of beta-cell function of pancreatic islets isolated from bank voles developing glucose intolerance/diabetes: an animal model showing features of both type 1 and type 2 diabetes mellitus, and a possible role of the Ljungan virus

General and Comparative Endocrinology
Martin BlixtS Sandler

Abstract

Bank voles (Clethrionomys glareolus) kept in captivity develop diabetes mellitus to a significant extent. Also in wild bank voles, elevated blood glucose has been observed. A newly isolated picornavirus named Ljungan virus (LV) has been found in the pancreas of these bank voles. Moreover, LV infection in combination with environmental factors may cause glucose intolerance/diabetes (GINT/D) in normal mice. The aim of the present study was to investigate the functional characteristics of pancreatic islets, isolated from bank voles, bred in the laboratory but considered LV infected. About 20% of all males and females were classified as GINT/D following a glucose tolerance test. Of these animals the majority had become diabetic by 20 weeks of age, with a tendency towards an earlier onset in the males. GINT/D animals had increased serum insulin levels. Islets were tested on the day of isolation (day 0) and after 1 week of culture for their insulin content and their capacity to synthesize (pro)insulin, secrete insulin and metabolize glucose. Functional differences could be observed between normal and GINT/D animals as well as between genders. An elevated basal insulin secretion was observed on day 0 indicating beta-cell dysfunction a...Continue Reading

References

Apr 1, 1983·Cryobiology·A Andersson, S Sandler
May 15, 2003·International Journal of Experimental Diabesity Research·Bo NiklassonAke Lernmark

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Citations

Apr 30, 2013·Acta Diabetologica·Johan HopfgartenOskar Skog
Feb 10, 2010·International Journal of Diabetes in Developing Countries·Oindrila RahaV R Rao
May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
Aug 10, 2016·Viral Immunology·Bo NiklassonWilliam Klitz
Aug 21, 2008·Journal of Medical Virology·German TapiaKjersti S Rønningen

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