Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Journal of Food Science and Technology
Kozo NakamuraToshifumi Aoyama

Abstract

Hypertension, hyperlipidemia, and diabetes are important precursors of cardiovascular disease. Here, we evaluated the antihypertensive, antihyperlipidemic, and antidiabetic potential of five types of sprouts in fructose-loaded spontaneously hypertensive rats (SHRs). Powdered sprouts (PSs) were produced from mung bean, broccoli, radish, and buckwheat sprouts and germinated soybeans by lyophilization. The PSs were analyzed for nutritional composition and bioactive agents (γ-aminobutyric acid [GABA], coenzyme Q10 [CoQ10], rutin, and myo-inositol-1,2,3,4,5,6-hexakisphosphate [IP6]) and functionally tested in SHRs given water containing 25 % fructose and diets containing 30 % PS for 46 days. All PSs were nutritionally rich in protein and dietary fiber. CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively. Mung bean, broccoli, and buckwheat PSs caused significant reductions in heart rates and/or serum triglycerides. Mung bean PS also significantly reduced serum total cholesterol. These data supported the antihypertensive and antihyperlipidemic potential of mung bean, broccoli, and buckwheat sprouts.

References

Apr 1, 1980·Metabolism: Clinical and Experimental·J SlederG M Reaven
Dec 22, 1999·Journal of Agricultural and Food Chemistry·P A KemmeA C Beynen
Feb 24, 2001·Bioscience, Biotechnology, and Biochemistry·N NishimuraS Kiriyama
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas BouchéHillel Fromm
Sep 1, 1957·Journal of Chronic Diseases·H E HILLEBOE
Sep 25, 2003·The Journal of Nutritional Biochemistry·Timo Vaskonen
Nov 19, 2003·Life Sciences·Machha AjayMohd Rais Mustafa
Feb 14, 2004·Journal of the American College of Nutrition·James W AndersonDavid J A Jenkins
Aug 17, 2005·Hypertension·Samer S NajjarEdward G Lakatta
Jan 26, 2008·Journal of Agricultural and Food Chemistry·Li-Yun LinRobert Y Peng
Jan 6, 2009·Journal of Agricultural and Food Chemistry·Chin-Lin HsuGow-Chin Yen
Jul 30, 2009·Pharmacology & Therapeutics·Adarsh KumarVarun Mohan
Sep 8, 2012·Food Chemistry·O N DonkorT Vasiljevic
Feb 26, 2013·Journal of Agricultural and Food Chemistry·Masahiro KoyamaKozo Nakamura
Jan 16, 2014·Journal of Food Science and Technology·Masahiro KoyamaKozo Nakamura

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Citations

Sep 15, 2017·Nutrients·Saleem Ali Banihani
Jul 18, 2020·Foods·Paulo E S MunekataJosé M Lorenzo
May 3, 2021·Journal of Food Biochemistry·Sumi Mekkara Nikarthil Sudhakaran, Devindra Shekappa Bukkan
Sep 24, 2021·Journal of Agricultural and Food Chemistry·Hui XuMingfu Wang

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