Characterization of biosynthesis and modes of action of prostaglandin E2 and prostacyclin in guinea pig mesenteric lymphatic vessels.

British Journal of Pharmacology
Sonia RehalP Y von der Weid

Abstract

Rhythmical transient constrictions of the lymphatic vessels provide the means for efficient lymph drainage and interstitial tissue fluid balance. This activity is critical during inflammation, to avoid or limit oedema resulting from increased vascular permeability, mediated by the release of various inflammatory mediators. In this study, we investigated the mechanisms by which prostaglandin E(2) (PGE(2)) and prostacyclin modulate lymphatic contractility in isolated guinea pig mesenteric lymphatic vessels. Quantitative RT-PCR was used to assess the expression of mRNA for enzymes and receptors involved in the production and action of PGE(2) and prostacyclin in mesenteric collecting lymphatic vessels. Frequency and amplitude of lymphatic vessel constriction were measured in the presence of these prostaglandins and the role of their respective EP and IP receptors assessed. Prostaglandin E(2) and prostacyclin decreased concentration-dependently the frequency, without affecting the amplitude, of lymphatic constriction. Data obtained in the presence of the EP(4) receptor antagonists, GW627368x (1 microM) and AH23848B (30 microM) and the IP receptor antagonist CAY10441 (0.1 microM) suggest that PGE(2) predominantly activates EP(4), whe...Continue Reading

References

Mar 1, 1989·British Journal of Pharmacology·R A Coleman, R L Sheldrick
Jan 1, 1987·Pathology and Immunopathology Research·M G Johnston
Sep 24, 1981·Nature·M G Johnston, J L Gordon
Feb 1, 1994·Prostaglandins·R A ColemanR L Sheldrick
Nov 1, 1993·The Journal of Physiology·D F Van Helden
Jun 1, 1996·The Journal of Physiology·P Y von der WeidD F Van Helden
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Aug 7, 2002·British Journal of Pharmacology·James L R Fox, Pierre-Yves von der Weid
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
May 29, 2003·British Journal of Pharmacology·Alice K Chan, Pierre-Yves von der Weid
Jan 28, 2004·British Journal of Pharmacology·Richard J DavisRobert A Coleman
Sep 17, 2004·Pharmacology & Therapeutics·Aaron N Hata, Richard M Breyer
Oct 7, 2004·European Journal of Pharmacology·Richard J WilsonHeather Giles
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kayoko HosakaDirk F van Helden
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Theresa F WuPierre-Yves von der Weid
Mar 31, 2007·Lymphatic Research and Biology·Véronique Angeli, Gwendalyn J Randolph
May 2, 2008·British Journal of Pharmacology·S P H AlexanderJ A Peters
May 10, 2008·American Journal of Respiratory and Critical Care Medicine·Ying-Ju LaiRalph Theo Schermuly
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Pierre-Yves von der WeidDirk F van Helden

❮ Previous
Next ❯

Citations

Dec 25, 2010·Journal of Applied Physiology·Elizabeth L CuretonGregory P Victorino
May 29, 2014·Lymphatic Research and Biology·Pierre-Yves von der WeidMichael J Davis
Oct 25, 2013·Angiogenesis·David AebischerCornelia Halin
Jan 23, 2014·Angiogenesis·Shan Liao, Pierre-Yves von der Weid
Mar 28, 2012·The Journal of Physiology·Pierre-Yves von der WeidMohammad S Imtiaz
Jan 28, 2014·Journal of Thrombosis and Haemostasis : JTH·A BorgognoneS P Watson
Aug 16, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joshua P Scallan, Michael J Davis
Jan 27, 2015·Seminars in Cell & Developmental Biology·Sanjukta ChakrabortyMariappan Muthuchamy
Dec 21, 2014·Prostaglandins & Other Lipid Mediators·Sonia Rehal, Pierre-Yves von der Weid
May 14, 2016·Virchows Archiv : an International Journal of Pathology·Lukasz A AdamczykUlrik Baandrup
Oct 27, 2010·Annals of the New York Academy of Sciences·Pierre-Yves Von Der Weid, Sonia Rehal
Apr 2, 2019·Experimental Lung Research·Tamami SakaiShinji Nakao
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan Mathias, Pierre-Yves von der Weid
Apr 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Haihui HanHao Xu
Jul 7, 2020·Frontiers in Immunology·Sarit PalAnatoliy A Gashev
Dec 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R M DongaonkarR H Stewart
Mar 14, 2019·Frontiers in Immunology·Simon Schwager, Michael Detmar
Jun 3, 2018·Cancer Metastasis Reviews·Peeyush K LalaMousumi Majumder
Oct 27, 2020·American Journal of Physiology. Renal Physiology·Elaine L SheltonValentina Kon
Apr 6, 2021·World Journal of Hepatology·Ramesh KumarRajeev Nayan Priyadarshi
Aug 21, 2021·Cardiovascular Research·Peter S RussellAnthony R J Phillips

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

The Journal of Physiology
P Y von der WeidMohammad S Imtiaz
Current Opinion in Gastroenterology
P Y von der WeidJosé Gp Ferraz
The International Journal of Biochemistry & Cell Biology
P Y von der Weid, David C Zawieja
© 2022 Meta ULC. All rights reserved