Abstract
ESBL-producing isolates of the Enterobacteriaceae occur throughout the world. The objectives of this study were to characterize uropathogenic Escherichia coli isolated at a tertiary care hospital in southern India, and shed light on blaCTX-M sequences of Indian origin. A cohort of 13 urinary isolates of E. coli (obtained from patients at the Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, Andhra Pradesh, India) were characterized and found to be resistant to multiple antibiotics, including extended-spectrum cephalosporins. All 13 isolates contained blaCTX-M-15, and many of them transferred this genotype to at least one laboratory strain of E. coli after conjugation. Analyses of blaCTX-M-15 sequences (n = 141) of Indian origin showed that > 85% of them were obtained from bacteria not associated with the urinary tract, and that E. coli isolates account for majority of all blaCTX-M-15-carrying bacteria reported from India. Other types of blaCTX-M appear to be rare in India, since only six such sequences were reported as of July 2015. The results indicate that 'selection pressure' exerted by extended-spectrum cephalosporins may have stabilized the blaCTX-M-15 genotype among E. coli in India. The rarity of other ...Continue Reading
References
Mar 18, 2000·International Journal of Antimicrobial Agents·L S TzouvelekisN J Legakis
Jun 9, 2004·Journal of Clinical Microbiology·François-Xavier WeillPatrick A D Grimont
Oct 7, 2004·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·T S DimitrovR Passadilla
Oct 12, 2005·International Journal of Food Microbiology·S AroraB Bist
Oct 13, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Noura Al SweihV O Rotimi
Oct 15, 2005·Clinical Microbiology Reviews·David L Paterson, Robert A Bonomo
Sep 1, 2006·Current Opinion in Microbiology·Rafael Cantón, Teresa M Coque
Oct 31, 2006·The Journal of Antimicrobial Chemotherapy·V M EnsorP M Hawkey
Mar 30, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J D D PitoutL Poirel
Dec 7, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mansour Al-ZarouniDebadatta Panigrahi
Jun 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James R JohnsonMariana Castanheira
Jan 22, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mubarak Saif AlfaresiAdeel Islam Abdulsalam
Aug 24, 2011·Antimicrobial Agents and Chemotherapy·Sally R PartridgeJonathan R Iredell
Jun 6, 2012·Current Drug Targets·Makrina TotsikaMark A Schembri
Jun 7, 2012·MBio·Danilo G MorielRino Rappuoli
Oct 10, 2012·Antimicrobial Agents and Chemotherapy·Arif HussainNiyaz Ahmed
May 4, 2013·BMC Infectious Diseases·Ashish PathakCecilia Stålsby Lundborg
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nicola K PettyScott A Beatson
May 6, 2014·International Journal of Antimicrobial Agents·Lena Dhara, Anusri Tripathi
Sep 4, 2015·The Journal of Infectious Diseases·Jan T Poolman, Michael Wacker
Apr 29, 2016·Journal of Pathogens·Kesavaram PadmavathySikhamani Rajasekaran
May 4, 2016·European Journal of Microbiology & Immunology·Maneesh Paul-SatyaseelaMalathi Jambulingam