Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Natali B BauerAndreas Moritz

Abstract

An experimental rat model served for evaluation of bone- and energy metabolism in early and late stages of osteoporosis. For the early stage, we hypothesized that bilateral ovariectomy (OVX)+multi-deficiency diet (OVXD; depletion of vitamin D, calcium, vitamin K, phosphorus) would induce increased bone turnover while the late stage would be characterized by enhanced bone catabolism. Obesity, insulin resistance and hyperleptinemia would be seen during the whole course of disease. Healthy female Sprague Dawley rats (n=41) aged 10 weeks were randomly assigned to sham and treatment groups and sacrificed at 3, 12, and 14 months after the study began. In the early phase, OVXD was associated with an increase in body weight, but not, however, in later stages. There was a decrease in bone mineral density and relative bone volume (BV/TV) as assessed by Dual Energy X-ray Absorptiometry and micro computed tomography that was most severe in the later stages of disease, indicating bone catabolism. Osteocalcin limiting bone formation was increased initially, whereas later stages (14 months) were characterized by elevated osteopontin, suggesting bone remodeling. Severe hyperparathyroidism was present during all stages of disease. Only the earl...Continue Reading

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Citations

Dec 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E A MarquesT B Harris
Jun 16, 2017·The American Journal of Pathology·Thaqif El KhassawnaChristian Heiss
Jul 6, 2018·Menopause : the Journal of the North American Menopause Society·Lisha YuQi Zhang
Nov 26, 2019·Reviews in Endocrine & Metabolic Disorders·Ebtesam Abdullah Al-Suhaimi, Meneerah Abdulrahman Al-Jafary

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