Characterization of bovine serum albumin epitopes and their role in allergic reactions

Allergy
P RestaniA Fiocchi

Abstract

This review provides updated information on conformational and sequential epitopes identified in bovine serum albumin (BSA) and summarizes available data about the role of structural modifications on BSA antigenicity/allergenicity. Data on beef allergy and BSA antigenicity are reported, with reference both to the basic literature and to clinical results obtained by our group. BSA is an important allergen involved in milk and beef allergy. The presence of conformational epitopes has been suggested by indirect evidence, while at least one sequential epitope has been experimentally identified. The role of structural modifications on BSA antigenicity is discussed as well as the increased tolerance observed in allergic subjects consuming beef as strained (homogenized) and freeze-dried derivatives. Study of the molecular characteristics of a known major allergen allows the identification of technological processes that may be capable of improving the tolerance of allergic subjects to a specific food. Even though any hoped for reduced allergenicity must be verified under medical supervision, the use of new products could obviate the need to avoid important foods such as meat in childhood.

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Citations

May 16, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·André-Bernard TonnelGabrielle Pauli
Dec 7, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ching-Feng HuangHo-Jen Peng
Dec 4, 2004·Allergy·A FiocchiA Martelli
Mar 9, 2012·Clinical and Molecular Allergy : CMA·Hana SalehGuha Krishnaswamy
Jul 7, 2009·Analytical and Bioanalytical Chemistry·Patrizia RestaniAlessandro Fiocchi
Apr 21, 2011·Current Opinion in Allergy and Clinical Immunology·Alessandro FiocchiPatrizia Restani
Jul 2, 2014·Journal of Immunological Methods·Rodrigo Scaliante MouraSamira Bührer-Sékula
May 31, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N SalvatoriM De Carli
Dec 17, 2009·Allergy·G-S ChoiH-S Park
Oct 5, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroaki MatsuoTakanori Taogoshi
Jul 3, 2013·Biochimica Et Biophysica Acta·Maksymilian ChruszczWladek Minor
Mar 13, 2010·Allergy, Asthma & Immunology Research·Gil-Soon ChoiHae-Sim Park
Jun 12, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P M MatricardiM Ollert
Apr 17, 2018·Critical Reviews in Food Science and Nutrition·Abdolkhalegh GolkarTodor Vasiljevic
Apr 30, 2019·Current Opinion in Allergy and Clinical Immunology·Alessandro Fiocchi, Motohiro Ebisawa
Feb 23, 2019·Materials·Joanna Dulińska-LitewkaAnna Karewicz
Jan 8, 2021·Clinical Reviews in Allergy & Immunology·Joana CostaThomas Holzhauser
Jan 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Caterina VillaIsabel Mafra
Nov 21, 2017·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Nour AlsabeehOrian Shirihai
Aug 17, 2021·Frontiers in Immunology·Utpal Kumar AdhikariMourad Tayebi

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