Characterization of brain-reactive autoantibodies in murine models of systemic lupus erythematosus.

Journal of Neuroimmunology
A Narendran, S A Hoffman

Abstract

Using the Western blot technique we analyzed the sera of five strains of mice that develop a disease like systemic lupus erythematosus (SLE), along with two normal strains, for their binding specificities against isolated mouse integral brain membrane proteins. This report describes the distribution and frequency of the more than 200 brain-reactive autoantibodies in the 126 animals tested and verifies the hypothesis of diversity in anti-brain antibodies produced during autoimmune conditions such as SLE. These results emphasize the importance of characterizing the brain-reactive autoantibodies in the sera or cerebrospinal fluid of SLE patients with central nervous system involvement.

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Citations

Nov 1, 1993·Physiology & Behavior·B SakićJ A Denburg
Dec 1, 1990·Journal of Neuroimmunology·S A Hoffman, C S Madsen
May 1, 1993·Journal of Neuroimmunology·N A Khin, S A Hoffman
Feb 11, 2003·Brain Research·David A BallokBoris Sakic
Apr 27, 1992·Journal of Immunological Methods·J Crimando, S A Hoffman
May 1, 1997·Neuroscience and Biobehavioral Reviews·B SakićJ A Denburg
Nov 6, 2001·Journal of Neuroimmunology·A Zameer, S A Hoffman
Sep 27, 2003·Journal of Neuroimmunology·Andleeb Zameer, Steven A Hoffman
Sep 11, 2003·Autoimmunity Reviews·Alexander Poletaev, Leeza Osipenko
Aug 14, 1997·Annals of the New York Academy of Sciences·P M Moore
Jun 9, 2014·BMC Immunology·Stephanie WilliamsSteven A Hoffman
May 1, 1992·Journal of Neuroimmunology·P M Moore
Jan 16, 2007·Brain Research Reviews·David A Ballok
Aug 15, 2006·Journal of Neuroimmunology·Xiaoxing MaBoris Sakic
Mar 7, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kui Liu, Chandra Mohan

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