Characterization of breast masses as benign or malignant at 3.0T MRI with whole-lesion histogram analysis of the apparent diffusion coefficient

Journal of Magnetic Resonance Imaging : JMRI
Shiteng SuoJianrong Xu

Abstract

To investigate the utility of whole-lesion apparent diffusion coefficient (ADC) histogram analysis in capturing breast lesion heterogeneity and determine which ADC metric may help best differentiate benign from malignant breast mass lesions at 3.0T magnetic resonance imaging (MRI). We retrospectively included 101 women with breast mass lesions (benign:malignant = 36:65) who underwent 3.0T diffusion-weighted imaging (DWI) and subsequently had histopathologic confirmation. ADC histogram parameters, including the mean, minimum, maximum, 10th/25th/50th/75th/90th percentile, skewness, kurtosis, and entropy ADCs, were derived for the whole-lesion volume in each patient. Mann-Whitney U-test, univariate and multivariate logistic regression, area under the receiver-operating characteristic curve (Az ), intraclass correlation coefficient (ICC), and Bland-Altman test were used for statistical analysis. Mean, minimum, maximum, and 10th/25th/50th/75th/90th percentile ADCs were significantly lower (all P < 0.0001), while skewness and entropy ADCs were significantly higher (P < 0.001 and P = 0.001, respectively) in malignant lesions compared with benign ones. The Az values of minimum and 25th percentile ADCs were significantly higher than tha...Continue Reading

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Citations

May 5, 2017·Journal of Magnetic Resonance Imaging : JMRI·Song LiuZhengyang Zhou
Oct 19, 2017·Journal of Magnetic Resonance Imaging : JMRI·Igor VidićPål Erik Goa
Nov 23, 2017·Journal of Magnetic Resonance Imaging : JMRI·Chunling LiuChuan Huang
Feb 3, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Georg Alexander GihrStefan Schob
Nov 21, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Feng WangJianyu Liu
Jan 7, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Tomohisa MoriyaKoichi Tokuuye
Jul 3, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Gao MaFei-Yun Wu
Mar 10, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Wei ZhangQing Feng
Aug 7, 2019·Journal of Magnetic Resonance Imaging : JMRI·Ting LiKangan Li
Feb 16, 2020·Journal of Magnetic Resonance Imaging : JMRI·Qian ZhangLijuan Zhou
Jan 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Habib RahbarSavannah C Partridge
Mar 14, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Xiaoguang LiJingqin Fang

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