PMID: 7541320Apr 18, 1995Paper

Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse

Brain Research. Developmental Brain Research
T HirataY Kitamura

Abstract

Previously, we showed that c-kit receptor tyrosine kinase is expressed by a subpopulation of dorsal root ganglion (DRG) neurons, and that the ligand for the c-kit receptor, stem cell factor (SCF), induces the neurite outgrowth and supports the survival of these neurons in culture [16]. However, it is unknown which class of DRG neurons express c-kit receptor and which factor regulates differentiation and survival of c-kit-positive neurons. In the present study, we attempted to characterize c-kit positive neurons in the mouse DRG. The c-kit-positive neurons were small or medium in size, and 44% of these neurons contained substance P. Central fibers of the c-kit-positive neurons terminated in laminae I and II of the gray matter of the spinal cord. These results suggest that c-kit-positive neurons in the DRG belong to a functional subpopulation. The c-kit receptor protein was presented on the membrane of processes and growth cones in neurons. When DRG cells of embryonic day 15.5 or 17.5 were cultured, the survival of c-kit-positive neurons was supported by SCF, nerve growth factor (NGF) or leukemia inhibitory factor. SCF and NGF synergistically supported the survival of c-kit-positive neurons at submaximal concentrations. c-kit-pos...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V Chan-Palay, S L Palay
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Oct 5, 1990·Cell·D E WilliamsH S Boswell
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TsaiS J Galli
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M MurphyP F Bartlett
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jun 1, 1989·Neuron·Y A Barde
Mar 1, 1988·Developmental Biology·H KurodaY Kitamura
Sep 1, 1987·The Journal of Comparative Neurology·K ChungR E Coggeshall
May 1, 1968·Archives of Biochemistry and Biophysics·E S Russell, S E Bernstein
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Korsching, H Thoenen
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L Shelton, L F Reichardt
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GoedertW Lichtensteiger
Apr 1, 1954·The Journal of Comparative Neurology·B REXED

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Citations

Aug 13, 2005·Development Genes and Evolution·Eve M Mellgren, Stephen L Johnson
Apr 19, 2005·American Journal of Respiratory Cell and Molecular Biology·Debbie L ChouLisa A Miller
Mar 5, 2005·BMC Gastroenterology·Willemijntje A HoogerwerfPankaj J Pasricha
Dec 21, 2012·Experimental & Translational Stroke Medicine·Chun-Shu PiaoLi-Ru Zhao
Jun 24, 2004·The Journal of Comparative Neurology·Hitoshi YamataniTatsumi Hirata
Oct 5, 2014·The Journal of Pain : Official Journal of the American Pain Society·Samridhi C GoswamiMichael J Iadarola
Dec 7, 2007·Neuron·Nevena MilenkovicAlistair N Garratt
Jul 28, 2007·Stroke; a Journal of Cerebral Circulation·Li-Ru ZhaoJohn A Kessler
Jan 1, 1997·Journal of Neuroscience Research·S C Zhang, S Fedoroff
Jan 24, 2003·American Journal of Physiology. Renal Physiology·Michael A PezzoneMatthew O Fraser
Nov 19, 2004·Development·Yvette M WilsonMark Murphy

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