Characterization of cannabinoid-1 receptors in the locus coeruleus: relationship with mu-opioid receptors.

Brain Research
Jillian L ScavoneElisabeth J Van Bockstaele

Abstract

The locus coeruleus (LC)-norepinephrine system is a target of both cannabinoid and opioid actions. The present study investigated the anatomical distribution of cannabinoid-1 receptor (CB1r) in the LC and its association with mu-opioid receptor (MOR). Immunoreactivity for CB1r was localized to pre- and postsynaptic cellular profiles in the LC, 82% of which were dual-labeled for tyrosine hydroxylase (TH). Of the CB1r-immunoreactive structures, 66% were somatodendritic profiles, 22% were axon terminals, and the remaining 12% were associated with glial and small unmyelinated axon-like structures. CB1r immunoreactivity (-ir) in somatodendritic profiles was more often localized to the cytoplasm, whereas CB1r-ir located in axon terminals was more commonly localized on the plasma membrane. Somatodendritic profiles with CB1r-ir typically received input from axon terminals forming asymmetric-type synapses. In contrast, presynaptic profiles with CB1r-ir typically formed symmetric synaptic specializations. Anatomical studies confirmed the co-existence of MOR and CB1r-ir in common somatodendritic compartments of catecholaminergic neurons in the LC, and also revealed CB1r-positive axon terminals forming synaptic contact with MOR-containing ...Continue Reading

References

Jun 28, 1992·Annals of the New York Academy of Sciences·S R ChildersS Ward
May 1, 1992·Trends in Neurosciences·G F KoobL Stinus
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R JahnP Greengard
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·U ArvidssonM W Wessendorf
Jun 6, 1995·European Journal of Pharmacology·A KumarB N Dhawan
Jan 1, 1994·Brain Research Bulletin·E J NestlerG K Aghajanian
Jul 1, 1998·Brain Research. Molecular Brain Research·J ManzanaresJ A Fuentes
Jul 3, 1999·Trends in Pharmacological Sciences·J ManzanaresJ A Fuentes
Nov 24, 1999·Biological Psychiatry·E J NestlerG K Aghajanian
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·A H LichtmanB R Martin
Jun 27, 2001·Nature Neuroscience·G Aston-JonesM L Oshinsky
Dec 12, 2001·Neuroscience·E J Van Bockstaele, K G Commons
Jan 31, 2002·Molecular Neurobiology·E J Van BockstaeleG Drolet
May 31, 2002·Pharmacological Reviews·A C HowlettR G Pertwee
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rafael Maldonado, Olga Valverde
Dec 4, 2003·Journal of Neuroimmunology·Paola MassiDaniela Parolaro
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gary Aston-JonesJ Patrick Card
Jul 9, 2004·Annals of the New York Academy of Sciences·A J DunnV Palamarchouk
Dec 8, 2004·Critical Reviews in Neurobiology·Javier CorcheroJosé A Fuentes
May 24, 2005·Journal of Pain and Symptom Management·Gavril W Pasternak
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·Daniela ViganòDaniela Parolaro
Aug 20, 2005·Life Sciences·Dirk G Demuth, Areles Molleman
Nov 18, 2005·European Journal of Pharmacology·Diana L CichewiczForrest L Smith
Feb 18, 2006·European Journal of Pharmacology·Aitziber Mendiguren, Joseba Pineda
Apr 15, 2006·The Journal of Comparative Neurology·Rodrigo A España, Craig W Berridge
May 19, 2006·The European Journal of Neuroscience·Anna Lisa MuntoniMarco Pistis

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Citations

Jul 2, 2011·The Journal of Biological Chemistry·G Cristina BrailoiuEugen Brailoiu
Jul 2, 2011·The Journal of Pharmacology and Experimental Therapeutics·Divya RameshAron H Lichtman
Sep 21, 2011·PloS One·Emmelie BjörklundChristopher J Fowler
Nov 5, 2013·European Journal of Pharmacology·Keith A SharkeyLinda A Parker
Jul 6, 2010·Psychopharmacology·Ana Franky CarvalhoElisabeth J Van Bockstaele
Dec 10, 2014·Expert Opinion on Drug Discovery·Ryan WyrofskyElisabeth J Van Bockstaele
Oct 21, 2015·Drug and Alcohol Dependence·Crystal J JichaSharon L Walsh
Feb 4, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ahmet DogrulAhmet Ulugol
Feb 3, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ana Franky Carvalho, Elisabeth J Van Bockstaele
Dec 3, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Susana Esteban, Jesús A García-Sevilla
Oct 11, 2011·Peptides·Richard J Bodnar
Jun 23, 2011·Neuroscience Letters·Ana Franky Carvalho, Elisabeth J Van Bockstaele
Jan 8, 2013·Journal of Neurochemistry·Frauke SteindelKrisztina Monory
Aug 19, 2014·The European Journal of Neuroscience·Alessandra M CathelLynn G Kirby
Dec 7, 2014·Drug and Alcohol Dependence·Thomas F GamageAron H Lichtman
May 29, 2016·Drug and Alcohol Dependence·Michelle R LofwallSharon L Walsh
Aug 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Arnau Busquets-GarciaAndrés Ozaita
Nov 18, 2017·Pharmacological Reports : PR·Claudio FerranteGiustino Orlando
Oct 2, 2019·Journal of Dual Diagnosis·Hye Bin YooFrancesca M Filbey
Oct 30, 2016·PLoS Computational Biology·Marieke JepmaSander Nieuwenhuis
Mar 14, 2020·Mini Reviews in Medicinal Chemistry·Ercan Ozdemir
Sep 11, 2017·Cellular and Molecular Neurobiology·Esther L SabbanIrit Akirav
Sep 18, 2018·Cannabis and Cannabinoid Research·Beth Wiese, Adrianne R Wilson-Poe
Dec 23, 2020·Journal of Neuroscience Research·Aida Mohammadkhani, Stephanie L Borgland
Dec 31, 2020·International Journal of Molecular Sciences·Alessandra GarganoAndras Bilkei-Gorzo
Mar 14, 2021·Journal of Neural Transmission·A A A Putri Laksmidewi, Andreas Soejitno
Jun 17, 2018·Neuroscience Letters·Hossein Mohammad-Pour KargarSaeed Semnanian
Mar 25, 2021·The European Journal of Neuroscience·William G WarrenChristine Stubbendorff

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