Characterization of Carriage Isolates of Neisseria meningitides in the Adolescents and Young Adults Population of Bogota (Colombia)

PloS One
Jaime MorenoAna Belén Ibarz-Pavon

Abstract

Meningococcal carriage studies are important to improve our understanding of the epidemiology of meningococcal disease. The aim of this study was to determine the prevalence of meningococcal carriage and the phenotypic and genotypic characteristics of isolates collected from a sample of students in the city of Bogotá, Colombia. A total of 1459 oropharyngeal samples were collected from students aged 15-21 years attending secondary schools and universities. Swabs were plated on a Thayer Martin agar and N. meningitidis was identified by standard microbiology methods and PCR. The overall carriage prevalence was 6.85%. Carriage was associated with cohabitation with smokers, and oral sex practices. Non-groupable and serogroup Y isolates were the most common capsule types found. Isolates presented a high genetic diversity, and circulation of the hypervirulent clonal complexes ST-23, ST-32 and ST-41/44 were detected. The meningococcal carriage rate was lower than those reported in Europe and Africa, but higher than in other Latin American countries. Our data also revealed antigenic and genetic diversity of the isolates and the circulation of strains belonging to clonal complexes commonly associated with meningococcal disease.

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Citations

Sep 30, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Camila F RizekMarta Heloisa Lopes
Apr 22, 2019·BMJ Open·Meagan E PetersonUNKNOWN Meningococcal Carriage Group
May 17, 2019·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·María Eugenia LeónUNKNOWN Grupo del laboratorio VIMENE Paraguay
Nov 17, 2020·Journal of Medical Microbiology·Eduardo Juscamayta-LópezRonnie Gavilán

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Methods Mentioned

BETA
PCR
dot blot

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Excel
SE
STATA

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