PMID: 6979669Jan 1, 1982Paper

Characterization of cells infiltrating the lungs of x-irradiated and nude mice after influenza virus infection

Microbiology and Immunology
E ShimomuraN Ishida

Abstract

After X-irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T-cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T-cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T-cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleen of T-cell deficient mice responded to concanavalin A. In the lungs of both X-irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.

References

Jan 1, 1978·Scandinavian Journal of Immunology·K L Yap, G L Ada
Nov 1, 1978·The Journal of Experimental Medicine·F A EnnisP Albrecht
Jan 1, 1976·The Journal of Infectious Diseases·J L SullivanF A Ennis
May 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·F SuzukiN Ishida
Mar 1, 1980·European Journal of Immunology·M KasaiT Tada

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Citations

Jan 11, 2007·Immunology and Cell Biology·Nicole L La GrutaPeter C Doherty
Jun 4, 1999·The American Journal of Chinese Medicine·M KobayashiF Suzuki
Mar 3, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·N PerioloE Baumeister
Apr 19, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa K RyanMary Jane K Selgrade
Apr 5, 1990·Journal of Molecular Biology·S M RedfordJ A Tainer
May 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew P DeBergeRichard I Enelow
Jul 1, 1983·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·S Charan, V M Mahajan
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·H B SulimanR J Folz

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