Characterization of cerebellar ataxia in chronic alcoholics using the International Cooperative Ataxia Rating Scale (ICARS)

Alcoholism, Clinical and Experimental Research
Lauren E FitzpatrickSimon F Crowe

Abstract

Alcoholism is the most common cause of cerebellar dysfunction, yet estimates of the incidence of alcoholic cerebellar degeneration (ACD) vary greatly, with differences in methodologies contributing to these disparate findings. This study set out to characterize the frequency and pattern of clinical signs of ACD in an alcoholic group using the International Cooperative Ataxia Rating Scale (ICARS). We compared the performance of 49 alcoholics and 29 control participants. The relative contributions of demographic and alcohol consumption variables to ICARS scores in the alcoholic group were also examined. The alcoholic group demonstrated significantly poorer performance on all of the ICARS subscales as compared with the control group. Within the alcoholic group, performance was more impaired on the speech scale than on all of the other scales, except the lower limb component of the kinetic scale, and less impaired on the oculomotor scale compared with all other scales. Years of heavy drinking and lifetime alcohol consumption correlated with total ICARS scores; however, maximum daily consumption was actually negatively correlated with ICARS scores. Of the alcohol history variables, years of heavy drinking was the best predictor of t...Continue Reading

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Citations

Feb 26, 2013·The Cerebellum·Lauren E Fitzpatrick, Simon F Crowe
May 1, 2016·Alcoholism, Clinical and Experimental Research·Kayle S SawyerEve M Valera
Jul 18, 2016·Journal of the Neurological Sciences·Oscar H Del BruttoNathan R King
Jun 4, 2014·Continuum : Lifelong Learning in Neurology·James M Noble, Louis H Weimer
Jan 1, 2014·Cerebellum & Ataxias·Volga TarlacElsdon Storey

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