Characterization of cerebral white matter lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis in comparison with multiple sclerosis and collagen-vasculitis: a semiquantitative MRI study

Journal of the Neurological Sciences
A J GodoyI Goto

Abstract

The brain lesions were studied by magnetic resonance imaging (MRI) in 29 HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 43 multiple sclerosis (MS) (11 with a primary progressive course: PPMS and 32 with a relapsing-remitting course: RRMS), 23 collagen-vasculitis and 54 HTLV-I-seronegative patients with other non-inflammatory neurological disorders (OND), according to the size of the lesions and their location in the brain (deep and subcortical white matter, periventricular white matter, infratentorial region and gray matter). Semiquantitative MRI analyses revealed the followings. (1) The frequency of either small or large lesions located in the periventricular as well as deep and subcortical white matter was significantly higher in HAM/TSP than in OND patients (p < 0.006, chi 2 test). In addition, the number of small lesions in the deep and subcortical, and periventricular white matter was significantly greater in HAM/TSP than in OND patients (p < 0.0003, Mann-Whitney U-test). (2) The HAM/TSP patients significantly exceeded the collagen-vasculitis patients in the frequency and the number of small lesions located in the periventricular region (p < 0.0001, chi 2 test, and p < 0.05, Mann-Whitney U-test, respe...Continue Reading

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Citations

Dec 13, 2005·Journal of Neurovirology·Francesca BagnatoSteven Jacobson
Jun 14, 2003·The Neurologist·R B KhanM C Levin
Apr 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·P CabreC R Newton
Mar 7, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Andrew K HowardJoël Oger
May 9, 2015·Neuroimaging Clinics of North America·Lázaro Luís Faria do AmaralAntonio Jose da Rocha
Sep 1, 1996·Multiple Sclerosis : Clinical and Laboratory Research·F E Leon-SM Osame
Apr 19, 2012·Arquivos de neuro-psiquiatria·Marzia Puccioni-SohlerCaterina Mainero
Oct 1, 2013·Dementia & Neuropsychologia·Ana Paula Silva ChampsJoão Gabriel Ramos Ribas
Jun 18, 1998·Arquivos de neuro-psiquiatria·A C FerrazR G Nogueira

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