PMID: 38852Jul 27, 1979

Characterization of cerebroside (monoglycosylceramide) from the sea anemone, Metridium senile. Identification of the major long-chain base as an unusual dienic base with a methyl branch at a double bond

Biochimica Et Biophysica Acta
K A KarlssonB E Samuelsson

Abstract

1. Cerebroside of the sea anemone, Metridium senile, has been isolated (0.6 mg/g dry tissue weight) and structurally characterized. 2. The structure was shown by mass spectrometry, NMR spectroscopy and degradative studies as beta-glucopyranosylceramide. The major fatty acids were 16 : 0 and 20 : 0 D-2-hydroxy fatty acids. The major base was a novel base, D-erythro-1,3-dihydroxy-2-amino-9-methyl-trans-4, trans-8-octadecadiene. 3. Some unusual fatty acids of marine origin are suggested to originate in this long-chain base by metabolic conversion. 4. The implication of the methyl branch position of the base on our current view of sphingolipid function in the plasma membrane is discussed.

References

Jul 1, 1989·Lipids·W M RatnayakeR G Ackman
Apr 1, 1992·Molecular and Biochemical Parasitology·E Barreto-BergterH Egge
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E Barreto-BergterP A Gorin
Apr 15, 2003·Chemistry and Physics of Lipids·S G BatrakovL A Galanina
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·Eliana Barreto-BergterMarcio L Rodrigues
Aug 24, 2018·Marine Drugs·Iván Cheng-Sánchez, Francisco Sarabia
Feb 19, 2010·Organic & Biomolecular Chemistry·Fiona J Black, Philip J Kocienski
Dec 29, 2004·Journal of Asian Natural Products Research·Ting JiangWen-Han Lin
Dec 13, 2005·The Journal of Biological Chemistry·Philipp TernesErnst Heinz

Related Concepts

Glucosylceramides
Cnidaria
Mass Spectrometry
Cerebrosides
Sea Anemones
Saturated Fat

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