Characterization of clay-based enterosorbents for the prevention of aflatoxicosis

Advances in Experimental Medicine and Biology
T D PhillipsP G Grant

Abstract

Appropriate chemical interventions that can block, retard, or significantly diminish foodborne exposure to aflatoxins are high priorities. A practical and effective approach to the aflatoxin problem has been the dietary inclusion of a processed calcium montmorillonite clay (HSCAS). HSCAS acts as an enterosorbent that rapidly and preferentially binds aflatoxins in the gastrointestinal tract resulting in decreased aflatoxin uptake and bioavailability. In mechanistic studies, we have shown that the intact dicarbonyl system in aflatoxin is essential for optimal sorption by HSCAS. Evidence also suggests that aflatoxins react at multiple sites on HSCAS clay surfaces (especially those within the interlayer region). Due to conceivable risks associated with the dietary inclusion of nonspecific binding agents, all aflatoxin enterosorbents should be tested in sensitive animal models for efficacy, safety, and the potential for nutrient interactions.

Citations

Jun 24, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·E Afriyie-GyawuT D Phillips
Oct 1, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas W KenslerJohn D Groopman
Jul 21, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·G JardA Lebrihi
Sep 8, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Abigael O AwuorLauren S Lewis
Apr 25, 2018·Journal of Dairy Science·I M OgunadeA T Adesogan
Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·Evans Afriyie-GyawuTimothy D Phillips
May 15, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·P WangT D Phillips
Oct 5, 2007·Annual Review of Public Health·John D GroopmanChristopher P Wild
Dec 20, 2018·International Journal of Veterinary Science and Medicine·Amany M DiabNagwan El-Habashi
Jun 19, 2004·Journal of Toxicology and Environmental Health. Part a·Melinda WilesTimothy Phillips
Nov 9, 2004·The American Journal of Clinical Nutrition·Jonathan H WilliamsDeepak Aggarwal
Jan 31, 2020·Frontiers in Microbiology·Zsolt RádulyLászló Csernoch
Feb 1, 2019·Clays and Clay Minerals·Timothy D PhillipsJia-Sheng Wang
Mar 7, 2003·Journal of the American Veterinary Medical Association·Allen K BinghamJohn E Bauer
Dec 23, 2006·Environmental Health Perspectives·Heather StrosniderDavid Wilson
Jan 30, 2013·Journal of Toxicology and Environmental Health. Part a·John F TaylorTimothy D Phillips
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A Marroquín-CardonaT D Phillips
Sep 14, 2007·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·E Afriyie-GyawuT D Phillips
Feb 21, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·T D PhillipsJ-S Wang
Jan 27, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Bernd WickleinEduardo Ruiz-Hitzky
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Mar 3, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kathy S XueJia-Sheng Wang
Jun 14, 2013·Journal of Agricultural and Food Chemistry·Bertrand GrenierIsabelle P Oswald
Apr 11, 2006·Biomacromolecules·Alexandros YiannikourisJean-Pierre Jouany

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