Characterization of clinical isolates of Mycobacterium tuberculosis from HIV positive individuals in Colombia, 2012

Biomédica : revista del Instituto Nacional de Salud
Claudia CastroGloria Puerto

Abstract

One third of the increase in tuberculosis cases is attributed to the spread of HIV. In 2012, 1,397 HIV-associated tuberculosis cases were reported in Colombia, i.e., 11.8% of the total cases. Molecular epidemiology tools help to understand the transmission of tuberculosis. To characterize clinical isolates of Mycobacterium tuberculosis derived from HIV-infected individuals, received at the Laboratorio Nacional de Referencia in the Instituto Nacional de Salud. This was a descriptive observational study. We analyzed 63 isolates of M. tuberculosis from HIV-infected individuals. Identification, drug susceptibility and genotyping assays were performed. Of the new cases evaluated, three (5.0%) were resistant to isoniazid combined with streptomycin; two (3.3%) to rifampicin, and one (1.6%) to isoniazid. Previously treated cases were sensitive. No multidrug resistance was evident. Among the predominant genotypes, 20 isolates were (31.7%) LAM9, eight (12.7%), H1, and seven (11.1%), T1. Nineteen isolates corresponded to orphan patterns. One single grouping was observed among tested isolates. We found no statistically significantdifference between the proportions of the antituberculous drug resistance and genotypes. We found resistant iso...Continue Reading

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Citations

Sep 6, 2018·Biomédica : revista del Instituto Nacional de Salud·Laura Plata-CasasÓscar Herrán-Falla
Jun 9, 2020·Tropical Medicine & International Health : TM & IH·Fátima M TenganWanderley M Bernardo
Sep 19, 2019·Biomédica : revista del Instituto Nacional de Salud·David Felipe García, Myriam Astudillo
Sep 19, 2019·Biomédica : revista del Instituto Nacional de Salud·Darío PuertoGloria Puerto
Jan 7, 2020·Pathogens and Global Health·M I Cerezo-CortésM I Murcia
Apr 12, 2020·Scientific Reports·Daniel Garzon-ChavezJacobus H de Waard
Nov 5, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Magda Beltrán-LeónMartha I Murcia

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