Abstract
Synaptic plasticity expressed as long-term potentiation (LTP) in the hippocampal-medial prefrontal cortex (mPFC) pathway is considered to be involved in cognitive function and learning and memory processes, but its synaptic mechanism remains unknown. The present study characterized LTP in the mPFC using the atypical antipsychotic clozapine, with a focus on dopaminergic modulation. The magnitude of LTP was facilitated by pretreatment with clozapine (20 mg/kg, i.p.), but not by the typical antipsychotic haloperidol (1 mg/kg, i.p.). Clozapine-induced LTP augmentation was blocked by the dopamine D(1) receptor antagonist SCH-23390 (10 microg/rat, i.c.v.), but not by the D(2) receptor antagonist remoxipride (10 microg/rat, i.c.v.) or the 5-HT(1A) receptor antagonist WAY-100635 (20 microg/rat, i.c.v.). SCH-23390 (10 microg/rat, i.c.v.) by itself did not affect LTP induction. The D(1) receptor agonist SKF-38393 (10 microg/kg, i.c.v.) facilitated LTP, mimicking the clozapine-induced response. Furthermore, in vivo microdialysis showed that transient increases in mPFC dopamine levels induced by tetanic stimulation sustained facilitation following clozapine administration (20 mg/kg, i.p.). These results demonstrate the importance of the D(...Continue Reading
References
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Lynch
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Feb 1, 1995·The European Journal of Neuroscience·T M JayS Laroche
Jan 1, 1993·Journal of Neural Transmission. General Section·W Hauber
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·B L MurphyR H Roth
Nov 5, 1997·Biological Psychiatry·A K MalhotraA Breier
Nov 24, 1998·Journal of Neural Transmission·P A Broderick, M F Piercey
Dec 16, 1998·European Journal of Pharmacology·B H WesterinkS K Long
Mar 19, 1999·European Journal of Pharmacology·M Watanabe, Y Hagino
Jun 12, 1999·Neuroscience·P ZhengW X Shi
Dec 3, 1999·The European Journal of Neuroscience·M TakitaS S Suzuki
May 2, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G L GessaM Pistis
Apr 21, 2001·Cerebral Cortex·J Wang, P O'Donnell
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G E JaskiwB K Yamamoto
Jun 12, 2001·Behavioural Brain Research·W E Pratt, S J Mizumori
Sep 5, 2001·The American Journal of Psychiatry·D C Goff, J T Coyle
Sep 18, 2001·Current Psychiatry Reports·D C Javitt
Dec 12, 2002·Biological Reviews of the Cambridge Philosophical Society·Satoru Otani
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stacy A Castner, Patricia S Goldman-Rakic
Apr 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F M M A van der HeijdenW M A Verhoeven
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yogita Chudasama, Trevor W Robbins
Sep 15, 2004·Brain Research·Young-Chul ChungJunji Ichikawa
Feb 25, 2005·Synapse·Machiko MatsumotoMitsuhiro Yoshioka
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Llorenç Díaz-MataixFrancesc Artigas
Citations
Apr 23, 2013·Journal of Physiology, Paris·Kevin BlotSatoru Otani
Jan 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yu OhmuraMitsuhiro Yoshioka
Feb 22, 2011·Pharmacogenomics·Fayçal MouaffakMarie Odile Krebs
Oct 12, 2013·Journal of Anesthesia·Hiroki ShikanaiHiroko Togashi
Oct 17, 2009·Biological Psychiatry·Yukiori GotoSatoru Otani
May 5, 2009·Brain Research·Yong LiuJingping Zhao
Mar 13, 2016·Brain Topography·Xiaxia XuTao Zhang
May 14, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rae PriceTarek K Rajji
Dec 26, 2009·Biological Psychiatry·Daphna ShohamyCarol Tamminga
Dec 18, 2010·Neuroscience·H KamiyamaH Togashi
May 5, 2017·PloS One·Marion RameBill P Godsil
Dec 22, 2009·Expert Review of Neurotherapeutics·S Kristian HillJohn A Sweeney
Sep 3, 2013·Biological & Pharmaceutical Bulletin·Hiroki ShikanaiHiroko Togashi
Aug 15, 2018·Neuropsychopharmacology Reports·Hiroki ShikanaiTakeshi Izumi