PMID: 9550263Apr 29, 1998Paper

Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon

Matrix Biology : Journal of the International Society for Matrix Biology
A D WaggettM Benjamin

Abstract

This study provides a unique correlation between a molecular biological and biochemical analysis of the extracellular matrix (ECM) macromolecules in one half of 28 human Achilles tendons with an immunohistochemical study of the other. Both the insertion site and the mid-tendon were studied. The insertion (enthesis) is characterized by three distinctive fibrocartilages, two in the tendon (enthesial and sesamoid) and one on the heel bone (periosteal). Thus, its structure contrasts markedly with the fibrous character of the mid-tendon. RT-PCR analyses were performed on RNA extracted from mid-tendon and from the tendon fibrocartilages to investigate transcription of collagens and proteoglycans. Western blotting was also used to identify and characterize these macromolecules, and immunohistochemistry to localize their distribution. The results demonstrate striking differences in the ECM between the mid-tendon and its insertion. Types I, III, V and VI collagens, decorin, biglycan, fibromodulin and lumican were found in both the mid-tendon and the fibrocartilages, although their precise distribution often differed with site. mRNA for type II collagen was constantly present in the fibrocartilages, but it was only found in the mid-tendo...Continue Reading

References

Oct 18, 1976·Biochemical and Biophysical Research Communications·B SykesR Smith
Aug 1, 1992·The Journal of Cell Biology·C M KieltyC A Shuttleworth
Jan 1, 1991·Annual Review of Biochemistry·L Kjellén, U Lindahl
Jan 1, 1990·Annals of the New York Academy of Sciences·R FleischmajerR Timpl
Dec 1, 1990·The Journal of Cell Biology·W B StallcupP Healy
Feb 1, 1990·Cell and Tissue Research·M RittigJ Mollenhauer
Jan 1, 1990·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·A L Osterman
Nov 1, 1987·The Journal of Cell Biology·D R KeeneR E Burgeson
Jan 1, 1989·International Review of Cytology·K G Vogel, T J Koob
Nov 1, 1988·The Journal of Hand Surgery·J M HunterE J Mackin
Jul 1, 1988·The American Journal of Sports Medicine·D B Miller
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·W B StallcupJ Levine
Mar 1, 1984·Collagen and Related Research·S AyadL Holt
Mar 1, 1983·Journal of the American Podiatry Association·S S ShamaH Lemont
Mar 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·K G VogelJ R Robbins
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A RufaiM Benjamin
Aug 1, 1994·Microscopy Research and Technique·P J Roughley, E R Lee
Jan 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·P J RoughleyA D Recklies
Oct 15, 1993·The Biochemical Journal·P J RoughleyJ S Mort
Jun 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M BenjaminM Irwin
Apr 1, 1996·Archives of Biochemistry and Biophysics·C Sagarriga ViscontiC Niyibizi
May 15, 1996·Biochemical and Biophysical Research Communications·C NiyibiziK Kavalkovich
Jul 16, 1996·Biochemical and Biophysical Research Communications·G J RucklidgeS P Robins
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M C BerensonK G Vogel
Jul 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·G J RucklidgeS P Robins
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo

❮ Previous
Next ❯

Citations

Sep 16, 1999·The Anatomical Record·S MilzM Benjamin
Sep 25, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A BurssensJ Victor
Sep 24, 2008·European Journal of Applied Physiology·Rita C MarquetiHeloisa S Selistre-de-Araujo
Jun 10, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Ian K Y LoCyril B Frank
Aug 21, 2013·Differentiation; Research in Biological Diversity·Yulia ShwartzElazar Zelzer
Feb 24, 2005·Journal of Shoulder and Elbow Surgery·Atsushi YokotaLouis J Soslowsky
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A DerwinA H Plaas
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S ThomopoulosL J Soslowsky
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M R DresslerG P Boivin
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stavros ThomopoulosLouis J Soslowsky
May 4, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A J HayesJ R Ralphs
May 16, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Katsuhiko AraiToyohiko Yoshihara
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M BenjaminJ R Ralphs
Feb 24, 1999·Journal of Anatomy·M Benjamin, J R Ralphs
Mar 29, 2001·Journal of Anatomy·S MilzM Benjamin
Jul 27, 2001·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·C E Evans, I A Trail
Nov 16, 2012·Tissue Engineering. Part a·Cevat EriskenHelen H Lu
Jul 20, 1999·Current Opinion in Rheumatology·D McGonagleP Emery
Sep 14, 2001·Current Opinion in Rheumatology·R J FrançoisM A Khan
Apr 17, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Piyawan ChatuparisuteStefan Milz
Dec 20, 2013·Journal of the Royal Society, Interface·Yanxin LiuGuy M Genin
Mar 31, 2005·Journal of Biomechanical Engineering·Ines M BasaloGerard A Ateshian
Jan 11, 2005·Annals of the Rheumatic Diseases·T BárdosT T Glant
May 7, 2013·Annual Review of Biomedical Engineering·Helen H Lu, Stavros Thomopoulos
Jun 27, 2006·Sports Medicine·Scott C WearingAndrew P Hills
Sep 20, 2011·Sports Medicine·Zudin PuthuchearyHugh E Montgomery
Nov 10, 2013·Journal of Biomechanics·Andrew P BreidenbachDavid L Butler
Sep 3, 2010·Cell and Tissue Research·Fernanda Martins de AlmeidaEdson Rosa Pimentel
Sep 1, 2014·Gene·Marilize C BurgerMalcolm Collins
Nov 13, 2002·Current Rheumatology Reports·Yiping ZhangA Robin Poole
Jan 31, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Ryan MarinovichHarvey A Goldberg
Mar 25, 2005·Journal of Biomedical Materials Research. Part a·S CristinoG Lisignoli
Jun 19, 2012·Journal of Biomechanics·Peter S TheobaldMichael D Jones
Jun 5, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Steven R CaliariBrendan A C Harley
Dec 6, 2011·Micron : the International Research and Review Journal for Microscopy·Adriano BiancalanaLaurecir Gomes

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